Reference: Donaldson AD (2005) Shaping time: chromatin structure and the DNA replication programme. Trends Genet 21(8):444-9

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Abstract


DNA is replicated according to a precise and reproducible temporal pattern. The S-phase programme has previously been analyzed in metazoan and yeast cells using different methods: cytological chromosome banding in human cells and DNA isotopic-labeling techniques in yeast. Microarray-based approaches for the analysis of the replication programme and chromatin structure are bringing us closer to a molecular understanding of the factors that determine replication time. In this article, I assess the impact of recent investigations and compare our knowledge of DNA replication-timing controls in yeast with those of metazoans.

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Comparative Study | Journal Article | Research Support, Non-U.S. Gov't | Review
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Donaldson AD
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