Reference: Asturias FJ (2004) RNA polymerase II structure, and organization of the preinitiation complex. Curr Opin Struct Biol 14(2):121-9

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Abstract


Recent X-ray and cryo-electron microscopy studies have provided information about the basal eukaryotic transcription machinery and about Mediator, the complex involved in transcription regulation during initiation. On the basis of this structural information, a model describing the minimal transcription complex and its interaction with Mediator has been proposed. The model provides insight into the possible mechanisms of transcription initiation and regulation.

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Journal Article | Review
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Asturias FJ
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