Although there is increasing evidence that eukaryotic gene order is not always random, there is no evidence that putatively favourable gene arrangements are preserved by selection more than expected by chance. In yeast (Saccharomyces cerevisiae), for example, co-expressed genes tend to be linked, but whether such gene pairs tend to remain linked more often than expected under null neutral expectations is not known. We show using gene pairs in the S. cerevisiae-Candida albicans comparison that highly co-expressed gene pairs are conserved as pairs at about twice the average rate. However, co-expressed genes also tend to be in close physical proximity and, as expected from a null neutral model, genes (be they co-expressed or not) that are physically close together tend to be retained more often. This physical proximity, however, only accounts for a small proportion of the enhanced degree of conservation of co-expressed gene pairs. These results demonstrate that purely neutralist models of gene order evolution are not realistic.
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Evidence ID | Analyze ID | Gene/Complex | Systematic Name/Complex Accession | Qualifier | Gene Ontology Term ID | Gene Ontology Term | Aspect | Annotation Extension | Evidence | Method | Source | Assigned On | Reference |
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Evidence ID | Analyze ID | Gene | Gene Systematic Name | Phenotype | Experiment Type | Experiment Type Category | Mutant Information | Strain Background | Chemical | Details | Reference |
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Evidence ID | Analyze ID | Gene | Gene Systematic Name | Disease Ontology Term | Disease Ontology Term ID | Qualifier | Evidence | Method | Source | Assigned On | Reference |
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Evidence ID | Analyze ID | Regulator | Regulator Systematic Name | Target | Target Systematic Name | Direction | Regulation of | Happens During | Regulator Type | Direction | Regulation Of | Happens During | Method | Evidence | Strain Background | Reference |
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Site | Modification | Modifier | Source | Reference |
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Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Source | Reference | Note |
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Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Assay | Annotation | Action | Modification | Source | Reference | Note |
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Complement ID | Locus ID | Gene | Species | Gene ID | Strain background | Direction | Details | Source | Reference |
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Evidence ID | Analyze ID | Dataset | Description | Keywords | Number of Conditions | Reference |
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