Reference: Wösten MM, et al. (2000) A signal transduction system that responds to extracellular iron. Cell 103(1):113-25

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Abstract


Iron is essential for all organisms but can be toxic in excess. Iron homeostasis is typically regulated by cytoplasmic iron binding proteins, but here we describe a signal transduction system (PmrA/PmrB) that responds to extracytoplasmic ferric iron. Iron promoted transcription of PmrA-activated genes and resistance to the antibiotic polymyxin in Salmonella. The PmrB protein bound iron via its periplasmic domain which harbors two copies of the sequence ExxE, a motif present in the Saccharomyces FTR1 iron transporter and in mammalian ferritin light chain. A pmrA mutant was hypersensitive to killing by iron but displayed wild-type resistance to a variety of oxidants, suggesting PmrA/PmrB controls a novel pathway mediating the avoidance of iron toxicity.

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Journal Article | Research Support, U.S. Gov't, P.H.S.
Authors
Wösten MM, Kox LF, Chamnongpol S, Soncini FC, Groisman EA
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