Life span in the yeast Saccharomyces cerevisiae is usually measured by the number of divisions individual cells complete. Four broad physiologic processes that determine yeast life span have been identified: metabolic control, resistance to stress, chromatin-dependent gene regulation, and genetic stability. A pathway of interorganelle communication involving mitochondria, the nucleus, and peroxisomes has provided a molecular mechanism of aging based on metabolic control. This pathway functions continuously, rather than as an on-off switch, in determining life span. The longevity gene RAS2 modulates this pathway. RAS2 also modulates a variety of other cellular processes, including stress responses and chromatin-dependent gene regulation. An optimal level of Ras2p activity is required for maximum longevity. This may be due to the integration of life maintenance processes by RAS2, which functions as a homeostatic device in yeast longevity. Loss of transcriptional silencing of heterochromatic regions of the genome is a mark of yeast aging. It is now clear that the functional status of chromatin plays an important role in aging. Changes in this functional status result in gene dysregulation, which can be altered by manipulation of the histone deacetylase genes. Silencing of ribosomal DNA appears to be of particular importance. Extrachromosomal ribosomal DNA circles are neither sufficient nor necessary for yeast aging.
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| Evidence ID | Analyze ID | Gene/Complex | Systematic Name/Complex Accession | Qualifier | Gene Ontology Term ID | Gene Ontology Term | Aspect | Annotation Extension | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Phenotype | Experiment Type | Experiment Type Category | Mutant Information | Strain Background | Chemical | Details | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Disease Ontology Term | Disease Ontology Term ID | Qualifier | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Regulator | Regulator Systematic Name | Target | Target Systematic Name | Direction | Regulation of | Happens During | Regulator Type | Direction | Regulation Of | Happens During | Method | Evidence | Strain Background | Reference |
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| Site | Modification | Modifier | Source | Reference |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Source | Reference | Note |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Assay | Annotation | Action | Modification | Source | Reference | Note |
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| Complement ID | Locus ID | Gene | Species | Gene ID | Strain background | Direction | Details | Source | Reference |
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| Evidence ID | Analyze ID | Dataset | Description | Keywords | Number of Conditions | Reference |
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