YNCQ0010W
- Systematic Name
- YNCQ0010W
- SGD ID
- SGD:S000007324
- Aliases
- tL(UAA)Q , tRNA-Leu
- Feature Type
- tRNA gene
- Description
- Mitochondrial leucine tRNA (tRNA-Leu); predicted by tRNAscan-SE analysis; required for mitochondrial translation and indirectly for maintenance of the mitochondrial genome; mutations in the orthologous human gene cause the neurological disease MELAS 1 2 3
- RNAcentral ID
- URS00004C1880
- Secondary Structure
-
- Comparative Info
-
Sequence
The S. cerevisiae Reference Genome sequence is derived from laboratory strain S288C. Download DNA or protein sequence, view genomic context and coordinates. Click "Sequence Details" to view all sequence information for this locus, including that for other strains.
Analyze Sequence
S288C only
BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes
S288C vs. other species
Alleles
Curated mutant alleles for the specified gene, listed alphabetically. Click on the allele name to open the allele page. Click "SGD search" to view all alleles in search results.
View all YNCQ0010W alleles in SGD search
Gene Ontology
GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code. SGD has manually curated and high-throughput GO Annotations, both derived from the literature, as well as computational, or predicted, annotations. Click "Gene Ontology Details" to view all GO information and evidence for this locus as well as biological processes it shares with other genes.
View computational annotations
Molecular Function
- Manually Curated
- enables ribosome binding (IDA)
- enables translation repressor activity (IDA)
- enables triplet codon-amino acid adaptor activity (ISM)
Biological Process
- Manually Curated
- involved in mitochondrial translation (IMP)
- involved in regulation of translation in response to stress (IDA)
- involved in translational elongation (IMP)
Cellular Component
- Manually Curated
- located in mitochondrion (IMP)
Phenotype
Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided. Click "Phenotype Details" to view all phenotype annotations and evidence for this locus as well as phenotypes it shares with other genes.
- Summary
- Non-essential gene; null mutants suffer mitochondrial dysfunction, cannot respire; reduction of function alleles that correspond to human mutations found in patients with neurodegenerative disease MELAS (mitochondrial 'Myopathy, Encephalopathy, Lactic Acidosis and Stroke-like episodes') cannot utilize glycerol as a carbon source
Classical Genetics
Disease
Disease Annotations consist of three mandatory components: a gene product, a term from the Disease Ontology (DO) controlled vocabulary and an evidence code. SGD provides manually curated DO Annotations derived from the literature. Click "Disease Details" to view all Disease information and evidence for this locus as well as diseases it shares with other genes.
- Summary
- Yeast tL(UAA)Q is homologous to human MT-TL1, and has been used to study MELAS syndrome, mitochondrial myopathy, and chronic progressive external ophthalmoplegia
Manually Curated
Interaction
Interaction annotations are curated by BioGRID and include physical or genetic interactions observed between at least two genes. An interaction annotation is composed of the interaction type, name of the interactor, assay type (e.g., Two-Hybrid), annotation type (e.g., manual or high-throughput), and a reference, as well as other experimental details. Click "Interaction Details" to view all interaction annotations and evidence for this locus, including an interaction visualization.
2 total interactions for 1 unique genes
Physical Interactions
- Protein-RNA: 1
Genetic Interactions
- Dosage Rescue: 1
Regulation
The number of putative Regulators (genes that regulate it) and Targets (genes it regulates) for the given locus, based on experimental evidence. This evidence includes data generated through high-throughput techniques. Click "Regulation Details" to view all regulation annotations, shared GO enrichment among regulation Targets, and a regulator/target diagram for the locus.
No regulation data available.
Literature
All manually curated literature for the specified gene, organized into topics according to their relevance to the gene (Primary Literature, Additional Literature, or Review). Click "Literature Details" to view all literature information for this locus, including shared literature between genes.