MAL63 / YSC0015 Overview


Standard Name
MAL63 1 3
Systematic Name
YSC0015
SGD ID
SGD:S000029659
Aliases
MALR 4
Description
MAL-activator protein; transcription factor; part of the complex locus MAL6, plays a positive role in the regulation of maltose fermentation 2
Name Description
MALtose fermentation 1
Gene Ontology Details

Gene Ontology

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code. SGD has manually curated and high-throughput GO Annotations, both derived from the literature, as well as computational, or predicted, annotations. Click "Gene Ontology Details" to view all GO information and evidence for this locus as well as biological processes it shares with other genes.


Molecular Function

Manually Curated

Biological Process

Manually Curated

Cellular Component

Manually Curated
Phenotype Details

Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided. Click "Phenotype Details" to view all phenotype annotations and evidence for this locus as well as phenotypes it shares with other genes.


No phenotype data available.

Interaction Details

Interaction

Interaction annotations are curated by BioGRID and include physical or genetic interactions observed between at least two genes. An interaction annotation is composed of the interaction type, name of the interactor, assay type (e.g., Two-Hybrid), annotation type (e.g., manual or high-throughput), and a reference, as well as other experimental details. Click "Interaction Details" to view all interaction annotations and evidence for this locus, including an interaction visualization.


No interaction data available.

Regulation Details

Regulation

The number of putative Regulators (genes that regulate it) and Targets (genes it regulates) for the given locus, based on experimental evidence. This evidence includes data generated through high-throughput techniques. Click "Regulation Details" to view all regulation annotations, shared GO enrichment among regulation Targets, and a regulator/target diagram for the locus.


Summary
MAL63 encodes a transcription factor that is a member of the C6 zinc finger class, containing a DNA binding domain also known as the Zn2Cys6 binuclear zinc cluster or zinc knuckle. In the presence of maltose, Mal63p positively regulates maltose fermentation by activating transcription of the MAL61 and MAL62 genes, which encode maltose permease and maltase, respectively. Mal63p binds as a dimer to three sites in the promoter region of these divergently transcribed genes. Mal63p activity is regulated by chaperone proteins. It first forms an early complex with Ssa1p and then transitions to an intermediate complex with Ssa1p, Hsp82p, and Sti1p (chaperones of the Hsp70, Hsp90, and Hop families). In the presence of maltose, transcriptionally active Mal63p is released from the intermediate complex. The cochaperone Aha1p negatively regulates Mal63p activity by inhibiting formation of the intermediate complex.
Regulators
1
Targets
0
Literature Details

Literature

All manually curated literature for the specified gene, organized into topics according to their relevance to the gene (Primary Literature, Additional Literature, or Review). Click "Literature Details" to view all literature information for this locus, including shared literature between genes.


Primary
22
Additional
18
Reviews
6

Resources