CDC40 / YDR364C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

Non-essential gene in S288C, but essential in the Sigma1278b background; null mutant has slow growth in S288C, and is unable to grow anaerobically; conditional mutants accumulate splicing intermediates and both SPBs and mitotic spindles are absent; homozygous conditional mutants have deceased microtubule staining, defects in meiotic recombination and chromosome segregation and are sensitive to treatment with MMS; null mutants have cell cycle defects in G1 and S phase, abnormally elongated buds, delayed bud emergence, decreased chronological lifespan, reduced survival in stationary phase, and decreased spontaneous direct-repeat recombination

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources