This page displays data from Segal et al and was kindly provided to SGD by Eran Segal.

Module 35 (23 Genes) - Stress Analysis

Jump to: Significant GO annotations | Significant Motif Binding Sites.

Predicted Regulatory Module

The control program is a set of gene products predicted to regulate the cluster of genes below. The prediction is based on the relationship between the expression of the regulator and the expression of genes in the cluster as described in Segal et al. In several instances, there is direct experimental evidence to corroborate the predicted function of the regulators. In this view, the regulators (circled gene products) are in a hierarchy according to their effects on gene expression in the experiments directly below them.

Jump to: Predicted Control Program | Significant Motif Binding Sites.

Significant GO Annotations
This table lists, in order of significance, all GO annotations enriched in this cluster at a pvalue below 0.01. For each significant GO annotation, this table displays the following statistics: the number of genes in the cluster with the annotation (Hits), the percentage of genes in the cluster with the annotation (Hits (%)), the total number of genes in the entire dataset with the annotation (Total) and the pvalue of the annotation enrichment.
GO Term	Ontology	Hits	Hits (%)	Total	Pvalue
protein folding	Biological Process	10	43.47	26	3.9183e-15
chaperone activity	Molecular Function	8	34.78	34	3.24694e-10
hydrolase activity\, acting on acid anhydrides\, involved in cellular and subcellular movement	Molecular Function	7	30.43	24	9.55797e-10
heat shock protein activity	Molecular Function	5	21.73	8	3.06344e-09
hydrolase activity\, acting on acid anhydrides	Molecular Function	7	30.43	76	4.20308e-06
enzyme activity	Molecular Function	16	69.56	644	2.33596e-05
SRP-dependent\, co-translational membrane targeting\, translocation	Biological Process	3	13.04	9	6.5006e-05
SRP-dependent\, co-translational membrane targeting	Biological Process	3	13.04	9	6.5006e-05
protein metabolism	Biological Process	12	52.17	409	0.000114874
co-translational membrane targeting	Biological Process	3	13.04	11	0.000125522
protein-membrane targeting	Biological Process	3	13.04	12	0.000165935
metabolism	Biological Process	19	82.60	1130	0.000538303
extracellular matrix	Cellular Component	8	34.78	219	0.000590871
basal lamina	Cellular Component	8	34.78	219	0.000590871
basement membrane	Cellular Component	8	34.78	219	0.000590871
hydrolase activity	Molecular Function	8	34.78	230	0.000814204
extracellular	Cellular Component	8	34.78	243	0.00116023
response to stress	Biological Process	6	26.08	167	0.00351322
oxidoreductase activity	Molecular Function	5	21.73	117	0.00388173
oxidoreductase activity\, acting on CH-OH group of donors	Molecular Function	3	13.04	40	0.00585352
physiological processes	Biological Process	21	91.30	1589	0.00672951

Jump to: Predicted Control Program | Significant GO Annotations.

Significant Motif Binding Sites
This table lists, in order of significance, all motif binding sites enriched in this cluster at a pvalue below 0.01. For each significant motif binding site, the following statistics are displayed: the number of genes in the cluster with the binding site in their promoter (Hits), the percentage of genes with the binding site in their promoter (Hits (%)), the total number of genes in the dataset with the binding site in their promoter (Total) and the pvalue of the binding site enrichment. To view the sequence logo for each motif, click on the motif name.
Motif	Source	Consensus	Hits	Hits (%)	Total	Pvalue
HSF_04	TRANSFAC	AGAACGTTCTAGAAC	8	34.78	224	0.000861243
HSF_05	TRANSFAC	GTTCTAGAACAGAAC	7	30.43	227	0.00422327
XBP1_Q2	TRANSFAC	CTTCGAG	16	69.56	828	0.000773777