Complex: ESCRT-I complex
Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.
- Curated by
- IntAct
- ComplexAc
- CPX-940
- Systematic Name
- MVB12:SRN2:STP22:VPS28
- SGD ID
- SGD:S000217915
- Aliases
- ESCRT-1 complex ; ESCRT-I complex ; ESCRT1 complex ; Endosomal sorting complex required for transport-I complex.
- Description
- The ESCRT machinery consists of ESCRT-0 (CPX-1622), -I (this complex), -II (CPX-1623), -III (CPX-1624) and -IV (VPS4 complex, CPX-334) and is required for the downregulation of cell-surface receptors and for the final membrane scission step during endocytosis. The ESCRT-I complex directs the lysosomal degradation of ubiquinated transmembrane proteins.
Complex Diagram
This diagram displays the protein subunits (blue) of the complex and how they interact with each other. Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. If a participant appears in the diagram with no lines connected to it, then its specific interactions with other participants are currently unknown.
Subunits
This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. A brief description is also provided for each participant in the table.
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| Subunit | Description | Stoichiometry |
|---|
Gene Ontology
Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. Click on a term for its definition and other objects annotated to that term.
- Molecular Function
-
- enables ubiquitin binding (IDA)
- Biological Process
-
- involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (IDA)
Shared Annotations
This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). The shared GO terms or subunits can be visualized separately using the radio button at the bottom of the graph. Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes.
References
List of references used specifically to curate the information on this page.
- Curtiss M, et al. (2007) Efficient cargo sorting by ESCRT-I and the subsequent release of ESCRT-I from multivesicular bodies requires the subunit Mvb12. Mol Biol Cell 18(2):636-45 PMID: 17135292
- Kostelansky MS, et al. (2007) Molecular architecture and functional model of the complete yeast ESCRT-I heterotetramer. Cell 129(3):485-98 PMID: 17442384
- Chu T, et al. (2006) New component of ESCRT-I regulates endosomal sorting complex assembly. J Cell Biol 175(5):815-23 PMID: 17145965
Resources
IntAct | ModelArchive | PDB:2CAZ | PDB:2F66 | PDB:2P22 ... Show all Show fewer