Complex: SCF-Cdc4 ubiquitin ligase complex
Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.
- Curated by
- SGD
- ComplexAc
- CPX-3234
- Systematic Name
- CDC4:CDC53:CDC34:HRT1:SKP1
- SGD ID
- SGD:S000217838
- Description
- SCF-Cdc4 is a member of the SCF (Skp1-Cullin-F-box) E3 ubiquitin ligase family, in which the F-box protein, Cdc4, forms the substrate recognition subunit. It is required for both G1/S and G2/M cell cycle transitions, when it ubiquitinates and targets to degradation its substrates such as SIC1, FAR1, CLN1/2 and CLB6. The active complex may be a homodimer.
Complex Diagram
This diagram displays the protein subunits (blue) of the complex and how they interact with each other. Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. If a participant appears in the diagram with no lines connected to it, then its specific interactions with other participants are currently unknown.
Subunits
This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. A brief description is also provided for each participant in the table.
Increase the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through its pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.
| Subunit | Description | Stoichiometry |
|---|
Gene Ontology
Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. Click on a term for its definition and other objects annotated to that term.
- Molecular Function
-
- enables ubiquitin protein ligase activity (IDA)
- Biological Process
-
- involved in G1/S transition of mitotic cell cycle (BSR)
- involved in G2/M transition of mitotic cell cycle (BSR)
- involved in ubiquitin-dependent protein catabolic process (IDA)
Shared Annotations
This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). The shared GO terms or subunits can be visualized separately using the radio button at the bottom of the graph. Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes.
References
List of references used specifically to curate the information on this page.
- Petroski MD and Deshaies RJ (2005) Function and regulation of cullin-RING ubiquitin ligases. Nat Rev Mol Cell Biol 6(1):9-20 PMID: 15688063
- Willems AR, et al. (2004) A hitchhiker's guide to the cullin ubiquitin ligases: SCF and its kin. Biochim Biophys Acta 1695(1-3):133-70 PMID: 15571813
- Skowyra D, et al. (1997) F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex. Cell 91(2):209-19 PMID: 9346238
Resources
IntAct | ModelArchive | PDB:1NEX | PDB:3MKS ... Show all Show fewer