Complex: CDC48-NPL4-UFD1 AAA ATPase complex
Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.
- Curated by
- IntAct
- ComplexAc
- CPX-2946
- Systematic Name
- 6xCDC48:NPL4:UFD1
- SGD ID
- SGD:S000218134
- Aliases
- CDC48(UFD1/NPL4) complex ; Cdc48-Ufd1-Npl4 complex ; Cdc48p-Npl4p-Ufd1p AAA ATPase complex ; UNC complex ; Ufd1-Npl4-Cdc48/p97 (UNC) complex
- Description
- A type II AAA ATPase that is involved in the dislocation/extraction step of its substrate proteins from cellular structures or multiprotein complexes into the cytosol where they are largely degraded by the proteasome. Recruited by the integral membrane protein UBX2 (Q04228) and interacts with ubiquitin ligase complexes involved in the endoplasmic reticulum-associated degradation (ERAD) pathway.
Complex Diagram
This diagram displays the protein subunits (blue) of the complex and how they interact with each other. Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. If a participant appears in the diagram with no lines connected to it, then its specific interactions with other participants are currently unknown.
Subunits
This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. A brief description is also provided for each participant in the table.
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| Subunit | Description | Stoichiometry |
|---|
Gene Ontology
Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. Click on a term for its definition and other objects annotated to that term.
- Molecular Function
-
- enables ATP binding (IPI)
- enables ATP hydrolysis activity (BSR)
- enables ubiquitin binding (IPI)
- Biological Process
-
- involved in ER-associated misfolded protein catabolic process (IDA)
- involved in ERAD pathway (IDA)
- involved in ubiquitin-dependent ERAD pathway (IDA)
Shared Annotations
This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). The shared GO terms or subunits can be visualized separately using the radio button at the bottom of the graph. Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes.
References
List of references used specifically to curate the information on this page.
- Higgins R, et al. (2020) The Cdc48 Complex Alleviates the Cytotoxicity of Misfolded Proteins by Regulating Ubiquitin Homeostasis. Cell Rep 32(2):107898 PMID: 32668237
- Twomey EC, et al. (2019) Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding. Science 365(6452) PMID: 31249135
- Finley D, et al. (2012) The ubiquitin-proteasome system of Saccharomyces cerevisiae. Genetics 192(2):319-60 PMID: 23028185
- Rape M, et al. (2001) Mobilization of processed, membrane-tethered SPT23 transcription factor by CDC48(UFD1/NPL4), a ubiquitin-selective chaperone. Cell 107(5):667-77 PMID: 11733065
Resources
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