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Complex: CBF3 complex

Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.

Curated by
IntAct
ComplexAc
CPX-1898
Systematic Name
CBF2:CEP3:CTF13:SKP1
SGD ID
SGD:S000217792
Aliases
CBF3A-CBF3B-CBF3C-SKP1 complex ; centromere DNA-binding protein complex CBF3
Description
Binds to the CDEIII DNA element, conserved between all yeast chromosomes, early in kinetochore assembly and acts as the the primary determinant of assembly. Binding of the CBF3 complex and presence of the unique N-terminal tails of the two CSE4 (P36012) molecules in the nucleosome could cooperate to induce a sharp bending of the centromeric DNA, thus creating a C-loop structure in which the CSE4 nucleosome is proximal to the plus end of the kinetochore. Alternatively, CSE4-nucleosomes are part of the highly phased array of nucleosomes on either side of the CEN-sequence, while CFB3 occupies CDEIII and additional Ndc10 molecules occupy the CDEII sites to form an extended binding platform. microtubule

Complex Diagram

This diagram displays the protein subunits (blue) of the complex and how they interact with each other. Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. If a participant appears in the diagram with no lines connected to it, then its specific interactions with other participants are currently unknown.

PDB Structure

When available from the Protein Data Bank (PDB), the physical structure of the macromolecular complex is displayed. Click on the image or link for further information about the physical structure.

6F07 6F07 6GYU 6GYU

Subunits

This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. A brief description is also provided for each participant in the table.

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Subunit Description Stoichiometry

Gene Ontology

Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. Click on a term for its definition and other objects annotated to that term.

Shared Annotations

This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). The shared GO terms or subunits can be visualized separately using the radio button at the bottom of the graph. Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes.

References

List of references used specifically to curate the information on this page.

External Identifiers

EMDB: EMD-0097

Resources

IntAct | ModelArchive | PDB:6F07 | PDB:6GYU