The Swi6 protein in fission yeast, Schizosaccharomyces pombe, contains a chromo domain, a motif first identified in Drosophila HP1 protein, which is thought to be involved with the formation of heterochromatin. The Swi6 protein also has been shown to be associated with centromeres, telomeres and mating-type loci. Therefore, we have employed Swi6 as a tool for studying chromatin dynamics in S. pombe. We have made a construct expressing Swi6 fused with green fluorescent protein (GFP) and followed the in vivo dynamics of this chimeric protein in living cells. We have demonstrated that the distribution of Swi6-GFP inside the nuclei altered during mitosis. Also, the distribution pattern is abolished in the presence of clr4 and rik1 mutations.