Thanks to the international sequencing collaboration, all the yeast genes are now known, in the limited sense that we have their nucleotide and/or amino acid sequences. The yeast biology community now thereby enters the post-genome era, where the generation, retrieval and use of genomic and functional information will necessarily undergo qualitative changes. As we enter this era, the yeast community is presented with a number of opportunities and challenges. SGD plans to find any and all knowledge associated with a particular sequence and to provide curation of the relevant literature to both the yeast and non-yeast researchers. The continuing addition of new literature on a gene can be automated if (and only if) yeast authors mention at a minimum Saccharomyces cerevisiae, and include proper gene names in their abstracts. These issues and plans for new SGD content and services in the future will be discussed.