Glucose repression in yeast is mediated both by the Mig1 repressor and by one or more parallel mechanisms (1). We have previously isolated mutations in three genes that affect Mig1-independent repression of gluconeogenic growth (2). Two of the genes, GIG2 and GIG3 encode cyclin C and its associated kinase. They are also known as Srb10/Ssn8 and Srb11/Ssn3 and are subunits of the RNA polymerase II mediator complex. The third gene, GIG1, also encodes a subunit of the mediator complex (2). During the cloning of these genes, we also isolated several multicopy suppressors that can restore the ability of snf1 mig1 gig cells to grow on galactose. Interestingly, two of the cloned suppressor genes encode new zinc finger proteins. Disruption of the first gene did not have any obvious effect. However, homology searches revealed that a very similar protein is encoded by one of the open reading frames sequenced by yeast genome project, the presence of which may explain the lack of a disruption phenotype. The two proteins have 30% overall similarity and almost identical zinc fingers. Disruption of the second gene that was isolated in our screen caused an increased resistance to 2-deoxyglucose, suggesting a partial derepression of the SUC2 gene. The disruption showed some synergism with a mig1 disruption, but the encoded protein is no more similar to Mig1 than to other zinc finger proteins. 1. Ronne, H. (1995) Trends in Genetics 11, 12-17. 2. Balciunas, D. and Ronne, H. (1995) Nucl. Acids Res. 23, 4421-4425.