Synteny patterns: A message from the past for today's interpretation of Yeast genomes.
Sophie Bracht (1), Fred Dietrich (2), Sylvia Voegeli (1), Anita Lerch (1), Riccarda Rischatsch (1), Iza Kaminski (1), Peter Philippsen (1)
(1) Applied Microbiology, Biozentrum, University Basel, Klingelbergstr. 50, Basel, 4056, Switzerland;
(2) Department of Molecular Genetics and Microbiology, Duke University, USA
We have sequenced and annotated the genome of the filamentous ascomycete Ashbya gossypii (http://agd.unibas.ch). Always two S. cerevisiae gene regions show synteny to A. gossypii which provides evidence for a common ancestor and for a genome duplication in the evolution of S. cerevisiae. The synteny map show 328 double breaks of synteny originating from translocation or inversion events in the A. gossypii lineage or in the precursor of S. cerevisiae prior to its genome duplication. It shows in addition 168 single breaks of synteny originating from translocation or inversion events in the S. cerevisiae lineage after genome duplication. The synteny map finally in S. cerevisiae shows, based on inferred ancient gene orders, which of the duplicated genes lost one copy and which did not. Combined with the identification of genome rearrangement break points this enabled us to identify non-rearranged or potentially rearranged promoter regions for orthologous genes. Such alteration in promoter sequences may be one of the determinants of fungal diversity.
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