ERG2/YMR202W Single Page Format

This page provides an alternative format to the SGD Locus Summary Page. Note that additional information may be available on or linked from the standard format SGD Locus Summary page.

Contents
Names and Identifiers

GO Annotations

Pathways

Summary Paragraph

Mutant Phenotypes

Interactions

Homologs

Protein Info (physical properties, transcript info)

PDB Homologs (protein structure info)

Motifs

Genome-wide Expression
(and other large-scale analyses)

Locus History (misc. notes)

Sequence Retrieval and Analysis

Map and Displays

Localization

Community Annotation

Literature Guide

Sequence Coordinates

ChrXIII: 667536 to 668204
CDS: 667536 - 668204

Click on map for expanded view

SGD ORF map GBrowse
SGD Locus Page

Names and Identifiers [TOP] [NEXT]
Standard Name Systematic Name Alias Feature Type SGDID

ERG2 YMR202W END11 ORF, Verified S000004815

Description
C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis

GO Annotations [TOP] [NEXT]
Molecular Function
Annotation(s) Reference(s) Evidence Assigned By
C-8 sterol isomerase activity DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms.
     IEA : Inferred from Electronic Annotation with EBI:IPR006716
Assigned on 2007-05-23 UniProtKB
Rahier A, et al. (2008) Identification of essential amino acid residues in a sterol 8,7-isomerase from Zea mays reveals functional homology and diversity with the isomerases of animal and fungal origin. Biochem J 414(2):247-59
       IMP : Inferred from Mutant Phenotype
Assigned on 2008-05-14 SGD
isomerase activity GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping.
     IEA : Inferred from Electronic Annotation with EBI:KW-0413
Assigned on 2007-05-23 UniProtKB
Biological Process
Annotation(s) Reference(s) Evidence Assigned By
alcohol metabolic process Huttenhower C and Troyanskaya OG (2009) Prediction of Gene Ontology annotations by integrating high-throughput datasets
   RCA : Reviewed Computational Analysis
Assigned on 2009-08-06 bioPIXIE_MEFIT
cellular metabolic compound salvage Huttenhower C and Troyanskaya OG (2009) Prediction of Gene Ontology annotations by integrating high-throughput datasets
   RCA : Reviewed Computational Analysis
Assigned on 2009-08-06 bioPIXIE_MEFIT
ergosterol biosynthetic process DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms.
     IEA : Inferred from Electronic Annotation with EBI:IPR006716
Assigned on 2007-05-23 UniProtKB
Rahier A, et al. (2008) Identification of essential amino acid residues in a sterol 8,7-isomerase from Zea mays reveals functional homology and diversity with the isomerases of animal and fungal origin. Biochem J 414(2):247-59
       IMP : Inferred from Mutant Phenotype
Assigned on 2008-05-14 SGD
lipid biosynthetic process GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping.
     IEA : Inferred from Electronic Annotation with EBI:KW-0444
Assigned on 2007-05-23 UniProtKB
steroid biosynthetic process GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping.
     IEA : Inferred from Electronic Annotation with EBI:KW-0752
Assigned on 2007-05-23 UniProtKB
sterol biosynthetic process GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping.
     IEA : Inferred from Electronic Annotation with EBI:KW-0756
Assigned on 2007-05-23 UniProtKB
Cellular Component
Annotation(s) Reference(s) Evidence Assigned By
endoplasmic reticulum Paltauf F, et al. (1992) "Regulation and compartmentalization of lipid synthesis in yeast." Pp. 415-500 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression, edited by Jones EW, Pringle JR and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
   TAS : Traceable Author Statement
Assigned on 2001-01-19 SGD
DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms.
     IEA : Inferred from Electronic Annotation with EBI:IPR006716
Assigned on 2008-04-01 UniProtKB
GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping.
     IEA : Inferred from Electronic Annotation with EBI:KW-0256
Assigned on 2008-04-01 UniProtKB
integral to membrane GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping.
     IEA : Inferred from Electronic Annotation with EBI:KW-0812
Assigned on 2008-04-01 UniProtKB
GOA curators and UniProt curators (2007) Gene Ontology annotation based on Swiss-Prot Subcellular Location vocabulary mapping.
     IEA : Inferred from Electronic Annotation with EBI:SL-9904
Assigned on 2009-10-01 UniProtKB
membrane GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping.
     IEA : Inferred from Electronic Annotation with EBI:KW-0472
Assigned on 2008-04-01 UniProtKB

Pathways [TOP] [NEXT]
ergosterol biosynthesis

Summary Paragraph [TOP] [NEXT]
SUMMARY PARAGRAPH for ERG2/YMR202W for ERG2
ERG2 encodes C-8 sterol isomerase, an enzyme that catalyzes the isomerization of the delta-8 double bond to the delta-7 position in an intermedate in ergosterol biosynthesis (1, 2, 3, 4, 5). The erg2 null mutant has been reported to be viable (1); erg2 null mutant cells are ergosterol auxotrophs, accumulate aberrant sterols, and show a competitive growth disadvantage compared to wild type cells (6, 7). The immunosuppressant drug SR 31747 causes yeast cells to accumulate the same aberrant sterols seen in erg2 mutants, and overproduction of Erg2p causes resistance to SR 31747 (6). Erg2p also binds a class of drugs known as sigma ligands, as does a related protein from guinea pig liver (8, 9). Expression of ERG2 increases several fold upon ergosterol depletion by starvation or SR 31747 treatment (10). Production of the human or murine emopamil-binding protein, or a related Arabidopsis protein, restores the ability of erg2 mutants to convert delta-8 sterols to delta-7 isomers (11, 12).
Last Updated: 2000-09-05

Basic References [TOP]
BASIC INFORMATION REFERENCES forERG2/YMR202W for ERG2
1) Ashman WH, et al. (1991) Cloning and disruption of the yeast C-8 sterol isomerase gene. Lipids 26(8):628-32

2) Arthington BA, et al. (1991) Nucleotide sequence of the gene encoding yeast C-8 sterol isomerase. Gene 107(1):173-4

3) Paltauf F, et al. (1992) "Regulation and compartmentalization of lipid synthesis in yeast." Pp. 415-500 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression, edited by Jones EW, Pringle JR and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press

4) Lees ND, et al. (1995) Cloning of the late genes in the ergosterol biosynthetic pathway of Saccharomyces cerevisiae--a review. Lipids 30(3):221-6

5) Parks LW, et al. (1995) Biochemical and physiological effects of sterol alterations in yeast--a review. Lipids 30(3):227-30

6) Silve S, et al. (1996) The immunosuppressant SR 31747 blocks cell proliferation by inhibiting a steroid isomerase in Saccharomyces cerevisiae. Mol Cell Biol 16(6):2719-27

7) Palermo LM, et al. (1997) Assessment of the essentiality of ERG genes late in ergosterol biosynthesis in Saccharomyces cerevisiae. Curr Genet 32(2):93-9

8) Moebius FF, et al. (1996) Yeast sterol C8-C7 isomerase: identification and characterization of a high-affinity binding site for enzyme inhibitors. Biochemistry 35(51):16871-8

9) Moebius FF, et al. (1997) High affinity of sigma 1-binding sites for sterol isomerization inhibitors: evidence for a pharmacological relationship with the yeast sterol C8-C7 isomerase. Br J Pharmacol 121(1):1-6

10) Soustre I, et al. (2000) Sterol metabolism and ERG2 gene regulation in the yeast Saccharomyces cerevisiae. FEBS Lett 470(2):102-6

11) Silve S, et al. (1996) Emopamil-binding protein, a mammalian protein that binds a series of structurally diverse neuroprotective agents, exhibits delta8-delta7 sterol isomerase activity in yeast. J Biol Chem 271(37):22434-40

12) Grebenok RJ, et al. (1998) Isolation and characterization of an Arabidopsis thaliana C-8,7 sterol isomerase: functional and structural similarities to mammalian C-8,7 sterol isomerase/emopamil-binding protein. Plant Mol Biol 38(5):807-15

Mutant Phenotypes [TOP] [NEXT]
Phenotype page for ERG2/YMR202W

Interactions: genetic, physical, and other gene-gene links. [TOP] [NEXT]
Interaction page for ERG2/YMR202W

Homologs [TOP] [NEXT]

Comparison Resources

Physical Properties and Transcript Information: predicted from sequence [TOP] [NEXT]
Protein Sequence Calculations
from Predicted Full length Translation

N-term MKFFPLL

C-term LLQNKKF

Length(aa) 222

MW(Da) 24,895

pI 5.83

Amino Acid Composition (full length)

GCG tools: PepPlot, Helical Wheel, PepStruct

Transcript Translation Calculations

Codon Bias 0.437

Codon Adaptation Index 0.297

Frequency of Optimal Codons 0.662

Hydropathicity of Protein 0.079

Aromaticity Score 0.135

10 20 30 40 50 | | | | | MKFFPLLLLIGVVGYIMNVLFTTWLPTNYMFDPKTLNEICNSVISKHNAA EGLSTEDLLQDVRDALASHYGDEYINRYVKEEWVFNNAGGAMGQMIILHA SVSEYLILFGTAVGTEGHTGVHFADDYFTILHGTQIAALPYATEAEVYTP GMTHHLKKGYAKQYSMPGGSFALELAQGWIPCMLPFGFLDTFSSTLDLYT LYRTVYLTARDMGKNLLQNKKF*

Protein Structures from PDB: proteins of known structure with sequence similarity to ERG2/YMR202W, based on Smith-Waterman analysis. [TOP] [NEXT]
No protein structure information available.

Genome-wide Expression and Other Large-Scale Analyses [TOP] [NEXT]

Functional Analysis
You can also search multiple datasets simultaneously using Expression Connection for expression studies or Function Junction for other large scale analyses.

Locus History (misc. notes) [TOP] [NEXT]
Nomenclature History
Standard Name Reference
ERG2 SGD (2007) Information without a citation in SGD

Standard Name	Reference
ERG2	SGD (2007) Information without a citation in SGD

Sequence Retrieval [TOP] [NEXT]
Sequence Type Output Format

Genomic DNA GCG | FASTA | NoHeader

Genomic DNA with 1 kb up and downstream GCG | FASTA | NoHeader

DNA coding sequence
(without introns, without flanking regions) GCG | FASTA | NoHeader

Protein Translation of ORF GCG | FASTA | NoHeader

6-Frame Translation(with Restriction Map) GCG

Restriction Fragment Sizes GCG

Sequence Analysis Tools
Sequence from other databases

Sequence ID Source

YMR202W SGD Systematic Sequence

855242 NCBI: Gene ID

NP_013929.1 NCBI: RefSeq protein version ID

NP_013929.1 NCBI: RefSeq protein version ID

6323858 NCBI: NCBI protein GI

Sequence from other databases
Sequence ID	Source
YMR202W	SGD Systematic Sequence
855242	NCBI: Gene ID
NP_013929.1	NCBI: RefSeq protein version ID
NP_013929.1	NCBI: RefSeq protein version ID
6323858	NCBI: NCBI protein GI

Map and Displays [TOP] [NEXT]
Physical, Genetic Maps: Chromosomal Feature Map GBrowse Combined Physical and Genetic Map Genetic Distance vs. Physical Distance Ratios
Similarity Viewers: Synteny Viewer Genomic Stripe View SAGE Results Map

Localization [TOP] [NEXT]

Localization Resources

Community Annotation [TOP] [NEXT]
No community annotation available.

Literature Guide: papers categorized by topic. [TOP]
Topics Reference Other Genes Addressed
106 curated references; 0 references not yet curated
Genetic Interactions
Mutants/Phenotypes
Hodg CA, et al. (2010) Integral membrane proteins Brr6 and Apq12 link assembly of the nuclear pore complex to lipid homeostasis in the endoplasmic reticulum. J Cell Sci 123(Pt 1):141-151
       |ACC1 |APQ12 |ARE1 |ARE2 |ARV1 |BRR6 |DGA1 |ELO1 |ERG3 |ERG4 |ERG5 |ERG6 |FEN1 |LRO1 |MORE
Regulation of
Zeng T and Li J (2010) Maximization of negative correlations in time-course gene expression data for enhancing understanding of molecular pathways. Nucleic Acids Res 38(1):e1
       |ACO2 |ADR1 |CAB2 |CAT8 |CIT1 |ERG26 |ERG27 |ERG4 |ERG5 |ERG6 |GCN4 |GTT1 |HAP1 |HAP3 |MORE
Genetic Interactions
Mutants/Phenotypes
Strains/Constructs
Abe F and Hiraki T (2009) Mechanistic role of ergosterol in membrane rigidity and cycloheximide resistance in Saccharomyces cerevisiae. Biochim Biophys Acta 1788(3):743-52
       |ERG3 |ERG4 |ERG5 |ERG6 |PDR5 |UPC2
Genetic Interactions
Mutants/Phenotypes
Regulatory Role
Strains/Constructs
Daicho K, et al. (2009) Sorting defects of the tryptophan permease Tat2 in an erg2 yeast mutant. FEMS Microbiol Lett 298(2):218-27
       |ERG3 |ERG4 |ERG5 |ERG6 |TAT2 |TRP1
Mutants/Phenotypes
Strains/Constructs
Ho CH, et al. (2009) A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds. Nat Biotechnol 27(4):369-77
       |EFT2 |ERG3 |FPR1 |MVD1 |RPL28
Mutants/Phenotypes
Strains/Constructs
Jones L, et al. (2009) Cdc42p is activated during vacuole membrane fusion in a sterol-dependent subreaction of priming. J Biol Chem
       |CDC42 |ERG3 |ERG4 |ERG5 |ERG6 |RDI1 |SEC17 |SEC18 |STE20
Genetic Interactions
Mutants/Phenotypes
Strains/Constructs
Padilla-Lopez S, et al. (2009) Genetic evidence for the requirement of the endocytic pathway in the uptake of coenzyme Q(6) in Saccharomyces cerevisiae. Biochim Biophys Acta 1788(6):1238-48
       |CAT5 |COQ3 |PEP12 |SEC18 |TLG2 |VPS45
Regulation of
Transcription
Rintala E, et al. (2009) Low oxygen levels as a trigger for enhancement of respiratory metabolism in Saccharomyces cerevisiae. BMC Genomics 10():461
       |AAT2 |ACO1 |ACS1 |ADH1 |ADH2 |AFR1 |AGA1 |AGA2 |ALD4 |ALD6 |ANT1 |ARE1 |ARN1 |ASH1 |MORE
Large-scale phenotype analysis
Tan SX, et al. (2009) Cu, Zn superoxide dismutase and NADP(H) homeostasis are required for tolerance of endoplasmic reticulum stress in Saccharomyces cerevisiae. Mol Biol Cell 20(5):1493-508
       |AAT2 |ADO1 |AIM26 |ALG7 |ARO2 |BCK1 |BUR2 |CCS1 |CNB1 |CNM67 |CRZ1 |CSG2 |ELP2 |ERG6 |MORE
Mutants/Phenotypes
Strains/Constructs
Teixeira MC, et al. (2009) Genome-wide identification of Saccharomyces cerevisiae genes required for maximal tolerance to ethanol. Appl Environ Microbiol 75(18):5761-72
       |AGP2 |ANP1 |ARC35 |BDP1 |BNA1 |CSL4 |CUP5 |CWC25 |ERG24 |FHL1 |FPS1 |GCN4 |GCR1 |GLY1 |MORE
Non-Fungal Related Genes/Proteins
Thorsen M, et al. (2009) Genetic basis of arsenite and cadmium tolerance in Saccharomyces cerevisiae. BMC Genomics 10:105
       |ACO1 |ADA2 |ADE8 |AKR1 |ARD1 |BIM1 |BRO1 |CCR4 |CHC1 |COQ6 |COX15 |CYS3 |DOA1 |ELM1 |MORE
Mutants/Phenotypes
Yoshikawa K, et al. (2009) Comprehensive phenotypic analysis for identification of genes affecting growth under ethanol stress in Saccharomyces cerevisiae. FEMS Yeast Res 9(1):32-44
       |ALD6 |ARO1 |ARO2 |ARO7 |COQ10 |COQ5 |COQ9 |COX11 |COX12 |COX14 |COX16 |COX18 |COX23 |COX7 |MORE
Cell Growth and Metabolism
Function/Process
Strains/Constructs
Zhang Z, et al. (2009) [Regulation role of sterol C-24 methyltransferase and sterol C-8 isomerase in the ergosterol biosynthesis of Saccharomyces cerevisiae] Wei Sheng Wu Xue Bao 49(8):1063-8
     |ERG6
Genetic Interactions
Addinall SG, et al. (2008) A Genomewide Suppressor and Enhancer Analysis of cdc13-1 Reveals Varied Cellular Processes Influencing Telomere Capping in Saccharomyces cerevisiae. Genetics 180(4):2251-66
       |APQ12 |ARC18 |ARV1 |ASC1 |ASE1 |BFA1 |BIM1 |BMH1 |BRE2 |BUB1 |BUB2 |BUB3 |BUD27 |CCS1 |MORE
Mutants/Phenotypes
Strains/Constructs
Grossmann G, et al. (2008) Plasma membrane microdomains regulate turnover of transport proteins in yeast. J Cell Biol 183(6):1075-88
       |CAN1 |CAX4 |COG1 |ELP6 |ERG24 |ERG5 |ERG6 |FUR4 |FYV6 |GOS1 |HNT3 |MDG1 |MNN10 |MNN11 |MORE
Fungal Related Genes/Proteins
Iwaki T, et al. (2008) Multiple functions of ergosterol in the fission yeast Schizosaccharomyces pombe. Microbiology 154(Pt 3):830-41
       |ERG3 |ERG4 |ERG5 |ERG6
Mutants/Phenotypes
Jin H, et al. (2008) Ergosterol promotes pheromone signaling and plasma membrane fusion in mating yeast. J Cell Biol 180(4):813-26
       |ERG3 |ERG6 |LCB1 |PRM1 |STE5
Cross-species Expression
Function/Process
Genetic Interactions
Mutants/Phenotypes
Non-Fungal Related Genes/Proteins
Protein Sequence Features
Strains/Constructs
Rahier A, et al. (2008) Identification of essential amino acid residues in a sterol 8,7-isomerase from Zea mays reveals functional homology and diversity with the isomerases of animal and fungal origin. Biochem J 414(2):247-59

Mutants/Phenotypes
Strains/Constructs
Ruotolo R, et al. (2008) Membrane transporters and protein traffic networks differentially affecting metal tolerance: a genomic phenotyping study in yeast. Genome Biol 9(4):R67
       |AAT2 |AFT1 |ALF1 |APL5 |APL6 |APM3 |APS3 |ARO2 |BCK1 |BUB3 |CCC2 |CCR4 |CDC10 |CLC1 |MORE
Mutants/Phenotypes
Strains/Constructs
Tang F, et al. (2008) A life-span extending form of autophagy employs the vacuole-vacuole fusion machinery. Autophagy 4(7):874-86
       |ATG1 |ATG10 |ATG11 |ATG15 |ATG17 |ATG22 |ATG7 |ATG8 |AVT3 |AVT4 |ERG28 |ERG5 |ERG6 |GSG1 |MORE
Genetic Interactions
Infection and Antifungals
Mutants/Phenotypes
Strains/Constructs
Welscher YM, et al. (2008) Natamycin Blocks Fungal Growth by Binding Specifically to Ergosterol without Permeabilizing the Membrane. J Biol Chem 283(10):6393-401
       |ERG3 |ERG4 |ERG5 |ERG6
Mutants/Phenotypes
Bishop AL, et al. (2007) Phenotypic heterogeneity can enhance rare-cell survival in 'stress-sensitive' yeast populations. Mol Microbiol 63(2):507-20
       |ADE12 |ADE2 |ADH5 |AGP2 |AIM10 |AIM7 |ARE2 |ATP1 |BUD5 |CBP6 |CCE1 |CCS1 |COX6 |CSE2 |MORE
Mutants/Phenotypes
Cheng V, et al. (2007) Genome-Wide Screen for Oxalate-Sensitive Mutants of Saccharomyces cerevisiae. Appl Environ Microbiol 73(18):5919-27
       |ADA2 |AFT1 |CCR4 |CDC40 |CNM67 |CTK3 |DRS2 |ERG24 |GLY1 |GON7 |HOM6 |KEM1 |MCH5 |MTQ2 |MORE
Regulation of
Transcription
Hickman MJ and Winston F (2007) Heme Levels Switch the Function of Hap1 of Saccharomyces cerevisiae between Transcriptional Activator and Transcriptional Repressor. Mol Cell Biol 27(21):7414-24
         |CYC1 |CYC8 |ERG11 |ERG5 |HAP1 |HSC82 |HSP82 |SSA1 |TUP1
RNA Levels and Processing
Liu X, et al. (2007) Genetic and Comparative Transcriptome Analysis of Bromodomain Factor 1 in the Salt Stress Response of Saccharomyces cerevisiae. Curr Microbiol 54(4):325-30
         |ACS2 |ADH2 |AGX1 |ALD2 |ALD3 |APE3 |ARI1 |ARO10 |ARO9 |ATG33 |BAP2 |BDF1 |BDF2 |BDH2 |MORE
Protein-Nucleic Acid Interactions
RNA Levels and Processing
Oeffinger M, et al. (2007) Comprehensive analysis of diverse ribonucleoprotein complexes. Nat Methods 4(11):951-6
       |ACB1 |ACT1 |ADE3 |AIM34 |ASH1 |ASM4 |BEM2 |BRR2 |BRX1 |BUD8 |CBC2 |CBF5 |CDC3 |CDC31 |MORE
Mutants/Phenotypes
Strains/Constructs
Pagani MA, et al. (2007) Disruption of iron homeostasis in Saccharomyces cerevisiae by high zinc levels: a genome-wide study. Mol Microbiol 65(2):521-37
       |ACO1 |ACO2 |ADE1 |ADE12 |ADE13 |ADE17 |ADE2 |ADE4 |ADE5,7 |ADE6 |ADK1 |AFT1 |AKR1 |ARN1 |MORE
Genetic Interactions
Mutants/Phenotypes
Strains/Constructs
Shah Alam Bhuiyan M, et al. (2007) Synthetically lethal interactions involving loss of the yeast ERG24: the sterol C-14 reductase gene. Lipids 42(1):69-76
         |ERG24 |ERG28 |ERG3 |ERG6 |SUR4
Large-scale phenotype analysis
Yadav J, et al. (2007) A phenomics approach in yeast links proton and calcium pump function in the Golgi. Mol Biol Cell 18(4):1480-9
           |CUP5 |ERG3 |ERG4 |ERG6 |GAL11 |GCN4 |GCN5 |HFI1 |NHP10 |OPI1 |PMR1 |RPN4 |SAC1 |SET3 |MORE
Regulation of
de Groot MJ, et al. (2007) Quantitative proteomics and transcriptomics of anaerobic and aerobic yeast cultures reveals post-transcriptional regulation of key cellular processes. Microbiology 153(Pt 11):3864-3878
         |ACO1 |ACO2 |ACS1 |ACS2 |ADE13 |ADE17 |ADE2 |ADE3 |ADE4 |ADE5,7 |ADE6 |ADH1 |ADH2 |ADH5 |MORE
Infection and Antifungals
Reviews
Carrillo-Munoz AJ, et al. (2006) Antifungal agents: mode of action in yeast cells. Rev Esp Quimioter 19(2):130-9
       |ERG11 |ERG24
Regulation of
Transcription
Davies BS and Rine J (2006) A role for sterol levels in oxygen sensing in Saccharomyces cerevisiae. Genetics 174(1):191-201
       |ANB1 |COX5B |DAN1 |ECM22 |ERG10 |ERG3 |HAP1 |IDI1 |MOT3 |TIR1 |UPC2
Function/Process
Mutants/Phenotypes
Strains/Constructs
Gatbonton T, et al. (2006) Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast. PLoS Genet 2(3):e35
         |AHC2 |APN1 |ARD1 |ARF1 |ATC1 |ATG17 |BRE1 |BUD21 |CBC2 |CDC73 |CHO2 |CTF8 |CYC8 |DCC1 |MORE
Mutants/Phenotypes
Rand JD and Grant CM (2006) The thioredoxin system protects ribosomes against stress-induced aggregation. Mol Biol Cell 17(1):387-401
       |AAT2 |ADH1 |ADK1 |AFR1 |AKR1 |ANP1 |APQ13 |ARO2 |ARP8 |ARV1 |ARX1 |ATP12 |ATP2 |BEM1 |MORE
Mutants/Phenotypes
Strains/Constructs
Sharma SC (2006) Implications of sterol structure for membrane lipid composition, fluidity and phospholipid asymmetry in Saccharomyces cerevisiae. FEMS Yeast Res 6(7):1047-51
       |ERG3 |ERG6
Mutants/Phenotypes
Strains/Constructs
Simons V, et al. (2006) Dual effects of plant steroidal alkaloids on Saccharomyces cerevisiae. Antimicrob Agents Chemother 50(8):2732-40
         |ERG3 |ERG6
Genetic Interactions
Mutants/Phenotypes
Valachovic M, et al. (2006) Cumulative mutations affecting sterol biosynthesis in the yeast Saccharomyces cerevisiae result in synthetic lethality that is suppressed by alterations in sphingolipid profiles. Genetics 173(4):1893-908
       |BCK2 |ECM22 |ERG28 |ERG4 |ERG5 |ERG6 |GDA1 |HAP1 |HDA3 |IES1 |RDN25-1 |RDN37-1 |RPN9 |SSN2 |MORE
Genetic Interactions
Warringer J and Blomberg A (2006) Involvement of yeast YOL151W/GRE2 in ergosterol metabolism. Yeast 23(5):389-98
       |BGL2 |ENO1 |ERG10 |ERG11 |ERG24 |ERG6 |GRE2 |HMG1 |HMG2 |HXK1 |MVD1 |RNR4 |TDH1
Mutants/Phenotypes
Regulation of
Strains/Constructs
Transcription
Davies BS, et al. (2005) Dual activators of the sterol biosynthetic pathway of Saccharomyces cerevisiae: similar activation/regulatory domains but different response mechanisms. Mol Cell Biol 25(16):7375-85
       |ECM22 |ERG3 |ERG4 |UPC2
Genetic Interactions
Mutants/Phenotypes
Strains/Constructs
Kishimoto T, et al. (2005) Defects in structural integrity of ergosterol and the Cdc50p-Drs2p putative phospholipid translocase cause accumulation of endocytic membranes, onto which actin patches are assembled in yeast. Mol Biol Cell 16(12):5592-609
       |ABP1 |ACT1 |BNI1 |CDC42 |CDC50 |DRS2 |ERG3 |ERG4 |ERG5 |ERG6 |GIC1 |LAS17 |SLA2 |SNC1
RNA Levels and Processing
Regulation of
Lai LC, et al. (2005) Dynamical remodeling of the transcriptome during short-term anaerobiosis in Saccharomyces cerevisiae: differential response and role of Msn2 and/or Msn4 and other factors in galactose and glucose media. Mol Cell Biol 25(10):4075-91
         |AAC1 |ADE1 |ADE12 |ADE17 |ADE4 |AFR1 |AIM17 |AIM3 |AKR1 |AKR2 |ALA1 |ALD5 |ARE1 |ARN1 |MORE
Fungal Related Genes/Proteins
MacPherson S, et al. (2005) Candida albicans zinc cluster protein Upc2p confers resistance to antifungal drugs and is an activator of ergosterol biosynthetic genes. Antimicrob Agents Chemother 49(5):1745-52
       |ECM22 |UPC2
Protein-protein Interactions
Techniques and Reagents
Mo C and Bard M (2005) A systematic study of yeast sterol biosynthetic protein-protein interactions using the split-ubiquitin system. Biochim Biophys Acta 1737(2-3):152-60
       |ERG1 |ERG11 |ERG24 |ERG25 |ERG26 |ERG27 |ERG28 |ERG3 |ERG4 |ERG5 |ERG6 |ERG7 |ERG9
Mutants/Phenotypes
Sano T, et al. (2005) Regulation of the sphingoid long-chain base kinase Lcb4p by ergosterol and heme: studies in phytosphingosine-resistant mutants. J Biol Chem 280(44):36674-82
       |DPL1 |ERG3 |ERG4 |ERG5 |ERG6 |HAP1 |HEM14 |HMG1 |KES1 |LCB3 |LCB4 |PBP1 |PDR5 |TPS1 |MORE
RNA Levels and Processing
Shobayashi M, et al. (2005) Effects of Culture Conditions on Ergosterol Biosynthesis by Saccharomyces cerevisiae. Biosci Biotechnol Biochem 69(12):2381-8
       |ERG13 |ERG20 |ERG24 |ERG26 |ERG28 |ERG3 |ERG5 |ERG6 |HMG1
Reviews
Dupre S, et al. (2004) Ubiquitin and endocytic internalization in yeast and animal cells. Biochim Biophys Acta 1695(1-3):89-111
           |ACT1 |AKR1 |AKR2 |ARC35 |ARK1 |ARP2 |ARP3 |BUL1 |BUL2 |CHC1 |CLC1 |CMD1 |EDE1 |END3 |MORE
Genetic Interactions
Mutants/Phenotypes
Giaever G, et al. (2004) Chemogenomic profiling: identifying the functional interactions of small molecules in yeast. Proc Natl Acad Sci U S A 101(3):793-8
           |DFR1 |ERG11 |ERG13 |ERG24 |FOL1 |FOL2 |HMG1 |HMG2 |MAL11 |MUS81 |NEO1 |PSO2 |RAD1 |RAD10 |MORE
RNA Levels and Processing
Regulation of
Jones DL, et al. (2004) Genome-Wide Analysis of the Effects of Heat Shock on a Saccharomyces cerevisiae Mutant With a Constitutively Activated cAMP-Dependent Pathway. Comp Funct Genomics 5(5):419-31
               |BTN2 |COX6 |DCS1 |ENO1 |ERG10 |ERG11 |ERG12 |ERG13 |ERG20 |ERG24 |ERG26 |ERG27 |ERG3 |ERG6 |MORE
RNA Levels and Processing
Techniques and Reagents
Krantz M, et al. (2004) Anaerobicity prepares Saccharomyces cerevisiae cells for faster adaptation to osmotic shock. Eukaryot Cell 3(6):1381-90
           |ALD2 |ALD3 |ALD4 |ALD6 |CTT1 |ERG1 |ERG10 |ERG11 |ERG12 |ERG13 |ERG20 |ERG24 |ERG25 |ERG26 |MORE
Function/Process
Kyoda K, et al. (2004) DBRF-MEGN method: an algorithm for deducing minimum equivalent gene networks from large-scale gene expression profiles of gene deletion mutants. Bioinformatics 20(16):2662-75
               |ADE2 |AEP2 |AFG3 |AFT1 |ALD4 |ALD5 |ASE1 |BUD22 |CKA2 |CKB2 |CUP5 |CYC8 |DIG1 |DIG2 |MORE
Mutants/Phenotypes
Lawrence CL, et al. (2004) Evidence of a new role for the high-osmolarity glycerol mitogen-activated protein kinase pathway in yeast: regulating adaptation to citric acid stress. Mol Cell Biol 24(8):3307-23
       |ADE4 |AFT1 |AIM18 |AMS1 |ARO2 |BCK1 |BMH1 |BMH2 |BUB1 |CAX4 |CCH1 |CCW14 |CKA1 |CLC1 |MORE
Mutants/Phenotypes
Serrano R, et al. (2004) Copper and iron are the limiting factors for growth of the yeast Saccharomyces cerevisiae in an alkaline environment. J Biol Chem 279(19):19698-704
           |AFT1 |ATX1 |BEM1 |BSD2 |BUD25 |CCC2 |CCS1 |COX17 |CTR1 |CUP5 |DIA2 |ERG6 |FET3 |FET4 |MORE
Fungal Related Genes/Proteins
Silver PM, et al. (2004) Role of Candida albicans transcription factor Upc2p in drug resistance and sterol metabolism. Eukaryot Cell 3(6):1391-7
       |ECM22 |ERG11 |UPC2
Genetic Interactions
Strains/Constructs
Tong AH, et al. (2004) Global mapping of the yeast genetic interaction network. Science 303(5659):808-13
           |AAD4 |AAH1 |ABF2 |ACE2 |ADH6 |AEP2 |AFG1 |AGP1 |AHC1 |AHC2 |AIM21 |AIM22 |AIM26 |AIM29 |MORE
Genetic Interactions
Mutants/Phenotypes
Valachovic M, et al. (2004) A mutation in sphingolipid synthesis suppresses defects in yeast ergosterol metabolism. Lipids 39(8):747-52
     |ECM22 |FEN1 |SUR4 |UPC2
Regulation of
Transcription
Agarwal AK, et al. (2003) Genome-wide expression profiling of the response to polyene, pyrimidine, azole, and echinocandin antifungal agents in Saccharomyces cerevisiae. J Biol Chem 278(37):34998-5015
         |AGA1 |AMS1 |ATF2 |AUS1 |BAG7 |BAP2 |BAP3 |CRH1 |CTR1 |CWP1 |CYB5 |DAN1 |DAN4 |ELO1 |MORE
Cellular Location
Other Features
Strains/Constructs
Shepard KA, et al. (2003) Widespread cytoplasmic mRNA transport in yeast: identification of 22 bud-localized transcripts using DNA microarray analysis. Proc Natl Acad Sci U S A 100(20):11429-34
         |ASH1 |BRO1 |CLB2 |CPS1 |DNM1 |EAR1 |EGT2 |IRC8 |IST2 |KSS1 |MET4 |MID2 |MMR1 |MTL1 |MORE
Function/Process
Mutants/Phenotypes
Strains/Constructs
Cinato E, et al. (2002) A DNA microarray-based approach to elucidate the effects of the immunosuppressant SR31747A on gene expression in Saccharomyces cerevisiae. Gene Expr 10(5-6):213-30

Mutants/Phenotypes
Strains/Constructs
Fleming JA, et al. (2002) Complementary whole-genome technologies reveal the cellular response to proteasome inhibition by PS-341. Proc Natl Acad Sci U S A 99(3):1461-6
             |APN1 |ATG17 |BEM4 |BIK1 |CCR4 |CDC26 |CHL1 |CHL4 |CLB2 |CLB5 |CSM3 |CTF19 |CTF8 |DCC1 |MORE
Function/Process
Regulation of
Transcription
Hongay C, et al. (2002) Mot3 is a transcriptional repressor of ergosterol biosynthetic genes and is required for normal vacuolar function in Saccharomyces cerevisiae. EMBO J 21(15):4114-24
       |ERG6 |ERG9 |MOT3 |PAN1 |VPS41
Function/Process
Mutants/Phenotypes
Strains/Constructs
Ruan B, et al. (2002) Alternative pathways of sterol synthesis in yeast. Use of C(27) sterol tracers to study aberrant double-bond migrations and evaluate their relative importance. Steroids 67(13-14):1109-19
         |ERG3 |ERG5
DNA/RNA Sequence Features
Function/Process
Protein-Nucleic Acid Interactions
Regulation of
Vik A and Rine J (2001) Upc2p and Ecm22p, dual regulators of sterol biosynthesis in Saccharomyces cerevisiae. Mol Cell Biol 21(19):6395-405
       |ECM22 |ERG3 |UPC2
Mutants/Phenotypes
RNA Levels and Processing
Strains/Constructs
Bammert GF and Fostel JM (2000) Genome-wide expression patterns in Saccharomyces cerevisiae: comparison of drug treatments and genetic alterations affecting biosynthesis of ergosterol. Antimicrob Agents Chemother 44(5):1255-65
       |ERG25 |ERG5 |ERG6 |RGI1 |TOS6
Regulation of
Transcription
Hughes TR, et al. (2000) Functional discovery via a compendium of expression profiles. Cell 102(1):109-26
           |AEP2 |BUD21 |COX23 |CUP5 |DIA4 |DSS1 |ERG28 |GET2 |HER2 |IMP2 |MAC1 |MRP7 |MRPL1 |MRPL13 |MORE
RNA Levels and Processing
Soustre I, et al. (2000) Sterol metabolism and ERG2 gene regulation in the yeast Saccharomyces cerevisiae. FEBS Lett 470(2):102-6

Function/Process
Mutants/Phenotypes
Reviews
Strains/Constructs
Dickson RC and Lester RL (1999) Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae. Biochim Biophys Acta 1438(3):305-21
       |AUR1 |CSG2 |DPL1 |FAS2 |FEN1 |IPT1 |LCB1 |LCB2 |LCB3 |LCB4 |LCB5 |MSN2 |MSN4 |MSS4 |MORE
Genomic expression study
Regulation of
Dimster-Denk D, et al. (1999) Comprehensive evaluation of isoprenoid biosynthesis regulation in Saccharomyces cerevisiae utilizing the Genome Reporter Matrix. J Lipid Res 40(5):850-60
       |ARE1 |ARE2 |BEM1 |BET2 |BET4 |BTS1 |CAT5 |CDC43 |COQ1 |COQ2 |COQ3 |COQ6 |COX10 |ERG1 |MORE
Mutants/Phenotypes
Strains/Constructs
Kaur R and Bachhawat AK (1999) The yeast multidrug resistance pump, Pdr5p, confers reduced drug resistance in erg mutants of Saccharomyces cerevisiae. Microbiology 145 ( Pt 4)():809-18
       |CHO1 |ERG3 |ERG4 |ERG6 |PDR5
Non-Fungal Related Genes/Proteins
Moebius FF, et al. (1999) Histidine77, glutamic acid81, glutamic acid123, threonine126, asparagine194, and tryptophan197 of the human emopamil binding protein are required for in vivo sterol delta 8-delta 7 isomerization. Biochemistry 38(3):1119-27

Function/Process
Genetic Interactions
Mutants/Phenotypes
Strains/Constructs
Munn AL, et al. (1999) Specific sterols required for the internalization step of endocytosis in yeast. Mol Biol Cell 10(11):3943-57
       |ERG6
Reviews
Daum G, et al. (1998) Biochemistry, cell biology and molecular biology of lipids of Saccharomyces cerevisiae. Yeast 14(16):1471-510
       |ACC1 |ACP1 |AUR1 |CDS1 |CEM1 |CHO1 |CHO2 |CKI1 |CPT1 |CRD1 |CSG2 |DPL1 |DPP1 |EPT1 |MORE
Reviews
Geli MI and Riezman H (1998) Endocytic internalization in yeast and animal cells: similar and different. J Cell Sci 111 ( Pt 8):1031-7
       |ACT1 |AKR1 |ARC35 |ARP2 |CHC1 |CLC1 |CMD1 |END3 |LCB1 |MYO5 |PAN1 |RVS161 |RVS167 |SAC6 |MORE
Non-Fungal Related Genes/Proteins
Grebenok RJ, et al. (1998) Isolation and characterization of an Arabidopsis thaliana C-8,7 sterol isomerase: functional and structural similarities to mammalian C-8,7 sterol isomerase/emopamil-binding protein. Plant Mol Biol 38(5):807-15

Non-Fungal Related Genes/Proteins
Other Features
Substrates/Ligands/Cofactors
Moebius FF, et al. (1998) Pharmacological analysis of sterol delta8-delta7 isomerase proteins with [3H]ifenprodil. Mol Pharmacol 54(3):591-8

Function/Process
Non-Fungal Related Genes/Proteins
Substrates/Ligands/Cofactors
Paul R, et al. (1998) Both the immunosuppressant SR31747 and the antiestrogen tamoxifen bind to an emopamil-insensitive site of mammalian Delta8-Delta7 sterol isomerase. J Pharmacol Exp Ther 285(3):1296-302

Non-Fungal Related Genes/Proteins
Jbilo O, et al. (1997) Purification and characterization of the human SR 31747A-binding protein. A nuclear membrane protein related to yeast sterol isomerase. J Biol Chem 272(43):27107-15

Non-Fungal Related Genes/Proteins
Moebius FF, et al. (1997) High affinity of sigma 1-binding sites for sterol isomerization inhibitors: evidence for a pharmacological relationship with the yeast sterol C8-C7 isomerase. Br J Pharmacol 121(1):1-6

Fungal Related Genes/Proteins
Mutants/Phenotypes
Palermo LM, et al. (1997) Assessment of the essentiality of ERG genes late in ergosterol biosynthesis in Saccharomyces cerevisiae. Curr Genet 32(2):93-9
       |ERG3
Fungal Related Genes/Proteins
Mutants/Phenotypes
Regulatory Role
Arthington-Skaggs BA, et al. (1996) Positive and negative regulation of a sterol biosynthetic gene (ERG3) in the post-squalene portion of the yeast ergosterol pathway. FEBS Lett 392(2):161-5
       |ARE1 |ARE2 |ERG3 |ERG4 |ERG5 |ERG6
Mutants/Phenotypes
Non-Fungal Related Genes/Proteins
Protein Sequence Features
Protein-protein Interactions
Regulation of
Moebius FF, et al. (1996) Yeast sterol C8-C7 isomerase: identification and characterization of a high-affinity binding site for enzyme inhibitors. Biochemistry 35(51):16871-8

Cross-species Expression
Non-Fungal Related Genes/Proteins
Silve S, et al. (1996) Emopamil-binding protein, a mammalian protein that binds a series of structurally diverse neuroprotective agents, exhibits delta8-delta7 sterol isomerase activity in yeast. J Biol Chem 271(37):22434-40

Genetic Interactions
Mutants/Phenotypes
Regulation of
Silve S, et al. (1996) The immunosuppressant SR 31747 blocks cell proliferation by inhibiting a steroid isomerase in Saccharomyces cerevisiae. Mol Cell Biol 16(6):2719-27
       |FEN1 |SUR4
Function/Process
Protein Physical Properties
Barrett-Bee K and Dixon G (1995) Ergosterol biosynthesis inhibition: a target for antifungal agents. Acta Biochim Pol 42(4):465-79
     |ERG1 |ERG11 |ERG24 |ERG3
Reviews
Lees ND, et al. (1995) Cloning of the late genes in the ergosterol biosynthetic pathway of Saccharomyces cerevisiae--a review. Lipids 30(3):221-6
     |ERG1 |ERG11 |ERG24 |ERG3 |ERG4 |ERG5 |ERG6 |ERG7 |ERG9 |FEN1 |FEN2
Reviews
Parks LW and Casey WM (1995) Physiological implications of sterol biosynthesis in yeast. Annu Rev Microbiol 49:95-116
       |ERG1 |ERG10 |ERG11 |ERG12 |ERG13 |ERG20 |ERG24 |ERG25 |ERG3 |ERG4 |ERG5 |ERG6 |ERG7 |ERG8 |MORE
Reviews
Parks LW, et al. (1995) Biochemical and physiological effects of sterol alterations in yeast--a review. Lipids 30(3):227-30
     |ERG1 |ERG10 |ERG11 |ERG12 |ERG20 |ERG24 |ERG3 |ERG4 |ERG5 |ERG6 |ERG7 |ERG8 |ERG9 |HMG1 |MORE
Mutants/Phenotypes
Kelly DE, et al. (1994) Investigation of the role of sterol delta 8-->7-isomerase in the sensitivity of Saccharomyces cerevisiae to fenpropimorph. FEMS Microbiol Lett 122(3):223-6

Non-Fungal Related Genes/Proteins
Keon JP, et al. (1994) Isolation of the ERG2 gene, encoding sterol delta 8-->delta 7 isomerase, from the rice blast fungus Magnaporthe grisea and its expression in the maize smut pathogen Ustilago maydis. Curr Genet 25(6):531-7

Fungal Related Genes/Proteins
Mutants/Phenotypes
Lai MH, et al. (1994) The identification of a gene family in the Saccharomyces cerevisiae ergosterol biosynthesis pathway. Gene 140(1):41-9
     |ERG24 |ERG4
Alias
Genetic Interactions
Mutants/Phenotypes
Strains/Constructs
Substrates/Ligands/Cofactors
Munn AL and Riezman H (1994) Endocytosis is required for the growth of vacuolar H(+)-ATPase-defective yeast: identification of six new END genes. J Cell Biol 127(2):373-86
       |ARC35 |END10 |LCB1 |VMA2 |VPS34 |VPS4 |VRP1
Fungal Related Genes/Proteins
Bard M, et al. (1993) Sterol synthesis and viability of erg11 (cytochrome P450 lanosterol demethylase) mutations in Saccharomyces cerevisiae and Candida albicans. Lipids 28(11):963-7
     |ERG11 |ERG24 |ERG3
DNA/RNA Sequence Features
Mapping
Heinisch JJ (1993) PFK2, ISP42, ERG2 and RAD14 are located on the right arm of chromosome XIII. Yeast 9(10):1103-5
     |PFK2 |RAD14 |TOM40
Genetic Interactions
Techniques and Reagents
Heiderpriem RW, et al. (1992) A simple method for the isolation of zymosterol from a sterol mutant of Saccharomyces cerevisiae. J Steroid Biochem Mol Biol 43(7):741-3
     |ERG6
Mutants/Phenotypes
Novotny C, et al. (1992) Effect of 5,7-unsaturated sterols on ethanol tolerance in Saccharomyces cerevisiae. Biotechnol Appl Biochem 15(3):314-20

Reviews
Paltauf F, et al. (1992) "Regulation and compartmentalization of lipid synthesis in yeast." Pp. 415-500 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression, edited by Jones EW, Pringle JR and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
   |ACC1 |ACH1 |CDS1 |CHO1 |CHO2 |CKI1 |CTR1 |ERG1 |ERG10 |ERG11 |ERG12 |ERG13 |ERG20 |ERG24 |MORE
DNA/RNA Sequence Features
Protein Sequence Features
Arthington BA, et al. (1991) Nucleotide sequence of the gene encoding yeast C-8 sterol isomerase. Gene 107(1):173-4

DNA/RNA Sequence Features
Function/Process
Mutants/Phenotypes
Protein Sequence Features
Strains/Constructs
Ashman WH, et al. (1991) Cloning and disruption of the yeast C-8 sterol isomerase gene. Lipids 26(8):628-32

Regulation of
Marcireau C, et al. (1990) In vivo effects of fenpropimorph on the yeast Saccharomyces cerevisiae and determination of the molecular basis of the antifungal property. Antimicrob Agents Chemother 34(6):989-93

Function/Process
Mutants/Phenotypes
Strains/Constructs
Mikhailova NP, et al. (1990) [Sterol level in Saccharomyces cerevisiae mutants with altered ergosterol biosynthesis] Prikl Biokhim Mikrobiol 26(3):360-3

Other Features
Nagai J, et al. (1981) Increased proportion of medium chain fatty acids in nystatin-resistant yeast mutants. Lipids 16(6):411-7
     |ERG5
Function/Process
Genetic Interactions
Mutants/Phenotypes
Strains/Constructs
Substrates/Ligands/Cofactors
Techniques and Reagents
Kleinhans FW, et al. (1979) ESR determinations of membrane permeability in a yeast sterol mutant. Chem Phys Lipids 23(2):143-54
     |ERG6
Function/Process
Genetic Interactions
Mutants/Phenotypes
Strains/Constructs
Substrates/Ligands/Cofactors
Lees ND, et al. (1979) ESR determination of membrane order parameter in yeast sterol mutants. Biochim Biophys Acta 553(3):469-75
     |ERG6
Other Features
Pierce AM, et al. (1979) Azasterol inhibitors in yeast. Inhibition of the delta 24-sterol methyltransferase and the 24-methylene sterol delta 24(28)-reductase in sterol mutants of Saccharomyces cerevisiae. Can J Biochem 57(3):201-8
     |ERG5 |ERG6
Function/Process
Mutants/Phenotypes
Strains/Constructs
Pierce AM, et al. (1979) Identification of ergosta-8,24(28)-dien-3 beta,6 alpha-diol in A delta 8 goes to delta 7 sterol isomerase-blocked yeast mutant. Lipids 14(10):876-9

Genetic Interactions
Mutants/Phenotypes
Bard M, et al. (1977) Sterol mutants of Saccharomyces cerevisiae: chromatographic analyses. Lipids 12(8):645-54
     |ERG3 |ERG5 |ERG6
Function/Process
Sobus MT, et al. (1977) Effects of the hypocholesteremic agent trifluperidol on the sterol, steryl ester, and fatty acid metabolism of Saccharomyces cerevisiae. J Bacteriol 130(3):1310-6

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SGD^tm pages Database Copyright © 1997-2010 The Board of Trustees of Leland Stanford Junior University. Permission to use the information contained in this database was given by the researchers/institutes who contributed or published the information. Users of the database are solely responsible for compliance with any copyright restrictions, including those applying to the author abstracts. Documents from this server are provided "AS-IS" without any warranty, expressed or implied. The SGD project at Stanford University is supported by a Genome Research Resource Grant from the US National Human Genome Research Institute, part of the US National Institutes of Health.