NDC1/YML031W Single Page Format

This page provides an alternative format to the SGD Locus Summary Page. Note that additional information may be available on or linked from the standard format SGD Locus Summary page.

Contents
Names and Identifiers

GO Annotations

Pathways

Summary Paragraph

Mutant Phenotypes

Interactions

Homologs

Protein Info (physical properties, transcript info)

PDB Homologs (protein structure info)

Motifs

Genome-wide Expression
(and other large-scale analyses)

Locus History (misc. notes)

Sequence Retrieval and Analysis

Map and Displays

Localization

Community Annotation

Literature Guide

Sequence Coordinates

ChrXIII: 214189 to 216156
CDS: 214189 - 216156
Genetic position: -18 cM
Genetic Map Data

Click on map for expanded view

SGD ORF map GBrowse
SGD Locus Page

Names and Identifiers [TOP] [NEXT]
Standard Name Systematic Name Alias Feature Type SGDID

NDC1 YML031W ORF, Verified S000004493

Description
Nuclear envelope protein with multiple putative transmembrane domains, required for nuclear pore complex assembly and spindle pole body duplication; required for meiosis II

GO Annotations [TOP] [NEXT]
Molecular Function
Annotation(s) Reference(s) Evidence Assigned By
structural constituent of cytoskeleton Chial HJ, et al. (1998) Saccharomyces cerevisiae Ndc1p is a shared component of nuclear pore complexes and spindle pole bodies. J Cell Biol 143(7):1789-800
       IPI : Inferred from Physical Interaction
Assigned on 2001-01-18 SGD
Biological Process
Annotation(s) Reference(s) Evidence Assigned By
RNA export from nucleus Chial HJ, et al. (1998) Saccharomyces cerevisiae Ndc1p is a shared component of nuclear pore complexes and spindle pole bodies. J Cell Biol 143(7):1789-800
       IPI : Inferred from Physical Interaction
Assigned on 2001-01-18 SGD
Fabre E and Hurt E (1997) Yeast genetics to dissect the nuclear pore complex and nucleocytoplasmic trafficking. Annu Rev Genet 31:277-313
     IPI : Inferred from Physical Interaction
Assigned on 2001-01-18 SGD
establishment of protein localization Huttenhower C and Troyanskaya OG (2009) Prediction of Gene Ontology annotations by integrating high-throughput datasets
   RCA : Reviewed Computational Analysis
Assigned on 2009-08-06 bioPIXIE_MEFIT
mRNA export from nucleus Tian W, et al. (2008) Combining guilt-by-association and guilt-by-profiling to predict Saccharomyces cerevisiae gene function. Genome Biol 9 Suppl 1:S7
             RCA : Reviewed Computational Analysis
Assigned on 2009-09-03 YeastFunc
mRNA transport GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping.
     IEA : Inferred from Electronic Annotation with EBI:KW-0509
Assigned on 2007-05-23 UniProtKB
Tian W, et al. (2008) Combining guilt-by-association and guilt-by-profiling to predict Saccharomyces cerevisiae gene function. Genome Biol 9 Suppl 1:S7
             RCA : Reviewed Computational Analysis
Assigned on 2009-09-03 YeastFunc
microtubule nucleation Chial HJ, et al. (1998) Saccharomyces cerevisiae Ndc1p is a shared component of nuclear pore complexes and spindle pole bodies. J Cell Biol 143(7):1789-800
       IPI : Inferred from Physical Interaction
Assigned on 2001-01-18 SGD
Winsor B and Schiebel E (1997) Review: an overview of the Saccharomyces cerevisiae microtubule and microfilament cytoskeleton. Yeast 13(5):399-434
       IPI : Inferred from Physical Interaction
Assigned on 2001-01-18 SGD
nuclear pore organization Tian W, et al. (2008) Combining guilt-by-association and guilt-by-profiling to predict Saccharomyces cerevisiae gene function. Genome Biol 9 Suppl 1:S7
             RCA : Reviewed Computational Analysis
Assigned on 2009-09-03 YeastFunc
nucleus organization Tian W, et al. (2008) Combining guilt-by-association and guilt-by-profiling to predict Saccharomyces cerevisiae gene function. Genome Biol 9 Suppl 1:S7
             RCA : Reviewed Computational Analysis
Assigned on 2009-09-03 YeastFunc
protein import into nucleus Chial HJ, et al. (1998) Saccharomyces cerevisiae Ndc1p is a shared component of nuclear pore complexes and spindle pole bodies. J Cell Biol 143(7):1789-800
       IPI : Inferred from Physical Interaction
Assigned on 2001-01-18 SGD
Fabre E and Hurt E (1997) Yeast genetics to dissect the nuclear pore complex and nucleocytoplasmic trafficking. Annu Rev Genet 31:277-313
     IPI : Inferred from Physical Interaction
Assigned on 2001-01-18 SGD
protein transport GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping.
     IEA : Inferred from Electronic Annotation with EBI:KW-0653
Assigned on 2007-05-23 UniProtKB
spindle pole body duplication in nuclear envelope Chial HJ, et al. (1998) Saccharomyces cerevisiae Ndc1p is a shared component of nuclear pore complexes and spindle pole bodies. J Cell Biol 143(7):1789-800
       IMP : Inferred from Mutant Phenotype
Assigned on 2001-01-18 SGD
transmembrane transport GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping.
     IEA : Inferred from Electronic Annotation with EBI:KW-0811
Assigned on 2009-10-01 UniProtKB
transport GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping.
     IEA : Inferred from Electronic Annotation with EBI:KW-0813
Assigned on 2007-05-23 UniProtKB
Cellular Component
Annotation(s) Reference(s) Evidence Assigned By
NDC1 complex Onischenko E, et al. (2009) Role of the Ndc1 interaction network in yeast nuclear pore complex assembly and maintenance. J Cell Biol 185(3):475-91
       IPI : Inferred from Physical Interaction with SGD:POM152, SGD:POM34
IDA : Inferred from Direct Assay
Assigned on 2009-07-01 SGD
cytoplasm GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping.
     IEA : Inferred from Electronic Annotation with EBI:KW-0963
Assigned on 2009-11-20 UniProtKB
cytoskeleton GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping.
     IEA : Inferred from Electronic Annotation with EBI:KW-0206
Assigned on 2009-11-20 UniProtKB
integral to membrane GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping.
     IEA : Inferred from Electronic Annotation with EBI:KW-0812
Assigned on 2007-05-23 UniProtKB
GOA curators and UniProt curators (2007) Gene Ontology annotation based on Swiss-Prot Subcellular Location vocabulary mapping.
     IEA : Inferred from Electronic Annotation with EBI:SL-9909
Assigned on 2009-10-01 UniProtKB
membrane GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping.
     IEA : Inferred from Electronic Annotation with EBI:KW-0472
Assigned on 2007-05-23 UniProtKB
nuclear pore Chial HJ, et al. (1998) Saccharomyces cerevisiae Ndc1p is a shared component of nuclear pore complexes and spindle pole bodies. J Cell Biol 143(7):1789-800
       IDA : Inferred from Direct Assay
Assigned on 2001-01-18 SGD
Rout MP, et al. (2000) The yeast nuclear pore complex: composition, architecture, and transport mechanism. J Cell Biol 148(4):635-51
       IDA : Inferred from Direct Assay
Assigned on 2002-06-17 SGD
GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping.
     IEA : Inferred from Electronic Annotation with EBI:KW-0906
Assigned on 2007-05-23 UniProtKB
GOA curators and UniProt curators (2007) Gene Ontology annotation based on Swiss-Prot Subcellular Location vocabulary mapping.
     IEA : Inferred from Electronic Annotation with EBI:SL-0185
Assigned on 2009-05-06 UniProtKB
nucleus GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping.
     IEA : Inferred from Electronic Annotation with EBI:KW-0539
Assigned on 2009-06-29 UniProtKB
spindle pole body Chial HJ, et al. (1998) Saccharomyces cerevisiae Ndc1p is a shared component of nuclear pore complexes and spindle pole bodies. J Cell Biol 143(7):1789-800
       IDA : Inferred from Direct Assay
Assigned on 2001-01-18 SGD
GOA curators and UniProt curators (2007) Gene Ontology annotation based on Swiss-Prot Subcellular Location vocabulary mapping.
     IEA : Inferred from Electronic Annotation with EBI:SL-0252
Assigned on 2009-05-06 UniProtKB

Pathways [TOP] [NEXT]
No pathways available

Summary Paragraph [TOP] [NEXT]
No summary paragraph available

Basic References [TOP]
BASIC INFORMATION REFERENCES forNDC1/YML031W for NDC1
1) Chial HJ, et al. (1999) Altered dosage of the Saccharomyces cerevisiae spindle pole body duplication gene, NDC1, leads to aneuploidy and polyploidy. Proc Natl Acad Sci U S A 96(18):10200-5

2) Thomas JH and Botstein D (1986) A gene required for the separation of chromosomes on the spindle apparatus in yeast. Cell 44(1):65-76

3) Lau CK, et al. (2004) A novel allele of Saccharomyces cerevisiae NDC1 reveals a potential role for the spindle pole body component Ndc1p in nuclear pore assembly. Eukaryot Cell 3(2):447-58

4) Hoyt, A. (1989) Personal Communication, Mortimer Map Edition 10

Mutant Phenotypes [TOP] [NEXT]
Phenotype page for NDC1/YML031W

Interactions: genetic, physical, and other gene-gene links. [TOP] [NEXT]
Interaction page for NDC1/YML031W

Homologs [TOP] [NEXT]

Comparison Resources

Physical Properties and Transcript Information: predicted from sequence [TOP] [NEXT]
Protein Sequence Calculations
from Predicted Full length Translation

N-term MIQTPRE

C-term SGNPNAT

Length(aa) 655

MW(Da) 74,133

pI 8.41

Amino Acid Composition (full length)

GCG tools: PepPlot, Helical Wheel, PepStruct

Transcript Translation Calculations

Codon Bias 0.066

Codon Adaptation Index 0.114

Frequency of Optimal Codons 0.441

Hydropathicity of Protein 0.005

Aromaticity Score 0.104

10 20 30 40 50 | | | | | MIQTPRELLNPRYTYHTIFSDVCKTRFNHLVTRLFFICSIIQTVVISLLA LPHSPLWELALAFIPNILALNLVSLLIIVTRKNYMHVKNFGFANSLTFIL GQLLSVKFLVYQGVYSMGSILLSFVLGVVFGRGGSGWKPYYKLFIWLVVP TIYNLQHHVTDADKLSFNCENFFQAPQDYVLERVKRIMEKSVILSVISMF VLPIFTTVFFSRQKSGLFDSFTNGVLAVTNLLIISCIIFITFEFINIAFD AHMSIGCLHKGKLISNLSSTPMETLLSGLSADKPFTRLTAYQELAYRATS LDPSLRAPIYHSKFRSSSGNTWSLILNECLKTIQINNEKVVQYLRSVQDL GGSATARHKKKVENLDYMYENGKLTSANERLFGNRPSMMAPLRDNGLLDE SPNRLRVRTDDSVLLNRGNKKRHRSSYYDNDLDETTQTFNGSIFTHETTF MTAMRLMLKKLKNSIMSFIFPSYAERQSSDESDNYRLLPNGSNKAQISII DIWSISKKRQAEKLVPLPICHANSVVALTGLLIRSKTEDPKGGIIASVGD ILKTLERSICALGEFADWDPESMAYTAFQTQRTAQDRVQQDSEDEDSMKD TTDMISVLYQLSTSAFMEIVLEYNVALNDVYLDADVAKLANWFLEVYASG NPNAT*

Protein Structures from PDB: proteins of known structure with sequence similarity to NDC1/YML031W, based on Smith-Waterman analysis. [TOP] [NEXT]
No protein structure information available.

Genome-wide Expression and Other Large-Scale Analyses [TOP] [NEXT]

Functional Analysis
You can also search multiple datasets simultaneously using Expression Connection for expression studies or Function Junction for other large scale analyses.

Locus History (misc. notes) [TOP] [NEXT]
Nomenclature History
Standard Name Reference
NDC1 Hoyt, A. (1989) Personal Communication, Mortimer Map Edition 10

Mapping Notes
Date Note
1989-10-01 Edition 10: ndc1 is physically adjacent to rad52
Mortimer RK, et al. (1989) Genetic map of Saccharomyces cerevisiae, edition 10. Yeast 5(5):321-403

Standard Name	Reference
NDC1	Hoyt, A. (1989) Personal Communication, Mortimer Map Edition 10

Date	Note
1989-10-01	Edition 10: ndc1 is physically adjacent to rad52 *Mortimer RK, et al.* (1989)** Genetic map of Saccharomyces cerevisiae, edition 10. Yeast 5(5):321-403

Sequence Retrieval [TOP] [NEXT]
Sequence Type Output Format

Genomic DNA GCG | FASTA | NoHeader

Genomic DNA with 1 kb up and downstream GCG | FASTA | NoHeader

DNA coding sequence
(without introns, without flanking regions) GCG | FASTA | NoHeader

Protein Translation of ORF GCG | FASTA | NoHeader

6-Frame Translation(with Restriction Map) GCG

Restriction Fragment Sizes GCG

Sequence Analysis Tools
Sequence from other databases

Sequence ID Source

YML031W SGD Systematic Sequence

854977 NCBI: Gene ID

NP_013681.1 NCBI: RefSeq protein version ID

NP_013681.1 NCBI: RefSeq protein version ID

6323610 NCBI: NCBI protein GI

Sequence from other databases
Sequence ID	Source
YML031W	SGD Systematic Sequence
854977	NCBI: Gene ID
NP_013681.1	NCBI: RefSeq protein version ID
NP_013681.1	NCBI: RefSeq protein version ID
6323610	NCBI: NCBI protein GI

Map and Displays [TOP] [NEXT]
Physical, Genetic Maps: Chromosomal Feature Map GBrowse Combined Physical and Genetic Map Genetic Distance vs. Physical Distance Ratios
Similarity Viewers: Synteny Viewer Genomic Stripe View SAGE Results Map

Localization [TOP] [NEXT]

Localization Resources

Community Annotation [TOP] [NEXT]
No community annotation available.

Literature Guide: papers categorized by topic. [TOP]
Topics Reference Other Genes Addressed
34 curated references; 0 references not yet curated
Cellular Location
Regulation of
Makio T, et al. (2009) The nucleoporins Nup170p and Nup157p are essential for nuclear pore complex assembly. J Cell Biol 185(3):459-73
       |APQ12 |ASM4 |GLE1 |KAP104 |KAP123 |KAP95 |MLP1 |NAB2 |NUP1 |NUP100 |NUP133 |NUP157 |NUP159 |NUP170 |MORE
Cellular Location
Protein-protein Interactions
Strains/Constructs
Onischenko E, et al. (2009) Role of the Ndc1 interaction network in yeast nuclear pore complex assembly and maintenance. J Cell Biol 185(3):475-91
       |ASM4 |MPS3 |NPL3 |NUP133 |NUP157 |NUP170 |NUP188 |NUP2 |NUP53 |NUP82 |POM152 |POM34
Reviews
Rexach M (2009) Piecing together nuclear pore complex assembly during interphase. J Cell Biol 185(3):377-9
       |ASM4 |NIC96 |NUP157 |NUP170 |NUP188 |NUP53 |NUP82 |NUP84 |POM152 |POM34 |RTN1 |YOP1
Cellular Location
Genetic Interactions
Mutants/Phenotypes
Strains/Constructs
Sezen B, et al. (2009) The SESA network links duplication of the yeast centrosome with the protein translation machinery. Genes Dev 23(13):1559-70
       |ASC1 |BBP1 |BFR1 |BRE5 |CDC33 |EAP1 |GCN4 |MLP1 |MLP2 |MPS2 |NIP1 |PGK1 |POM152 |POM34 |MORE
Mutants/Phenotypes
Strains/Constructs
Breslow DK, et al. (2008) A comprehensive strategy enabling high-resolution functional analysis of the yeast genome. Nat Methods 5(8):711-8
       |AAR2 |ABD1 |ABF1 |ACC1 |ACP1 |ADE13 |AFG2 |ALA1 |ALG1 |ALG13 |ALG14 |ALG2 |ALG7 |ALR1 |MORE
Protein-protein Interactions
Patel SS and Rexach MF (2008) Discovering novel interactions at the nuclear pore complex using bead halo: a rapid method for detecting molecular interactions of high and low affinity at equilibrium. Mol Cell Proteomics 7(1):121-31
       |ASM4 |GLE1 |KAP95 |NIC96 |NSP1 |NUP1 |NUP100 |NUP116 |NUP53 |NUP60 |NUP84 |POM34 |SEH1 |SRM1 |MORE
Cellular Location
Computational analysis
Protein Physical Properties
Protein-protein Interactions
Protein/Nucleic Acid Structure
Alber F, et al. (2007) Determining the architectures of macromolecular assemblies. Nature 450(7170):683-94
           |ASM4 |GLE1 |GLE2 |NIC96 |NSP1 |NUP1 |NUP100 |NUP116 |NUP120 |NUP133 |NUP145 |NUP157 |NUP159 |NUP170 |MORE
Cellular Location
Evolution
Protein/Nucleic Acid Structure
Alber F, et al. (2007) The molecular architecture of the nuclear pore complex. Nature 450(7170):695-701
           |ASM4 |GLE1 |GLE2 |NIC96 |NSP1 |NUP1 |NUP100 |NUP116 |NUP120 |NUP133 |NUP145 |NUP157 |NUP159 |NUP170 |MORE
Large-scale protein localization
Lind K and Norbeck J (2007) Immuno-qPCR detection of the tandem affinity purification (TAP)-tag as a sensitive and accurate tool suitable for large-scale protein quantification. Proteomics 7(24):4414-23
       |ARH1 |CDC13 |CDC23 |CDC27 |CLF1 |CTT1 |DAK1 |ERG8 |FPS1 |HOR2 |HXK2 |HXT1 |HXT7 |MCD1 |MORE
Cellular Location
Function/Process
Protein Sequence Features
Protein-protein Interactions
Patel SS, et al. (2007) Natively unfolded nucleoporins gate protein diffusion across the nuclear pore complex. Cell 129(1):83-96
         |GLE1 |GLE2 |KAP95 |NIC96 |NSP1 |NUP1 |NUP100 |NUP116 |NUP120 |NUP157 |NUP159 |NUP170 |NUP192 |NUP2 |MORE
Reviews
Taddei A (2007) Active genes at the nuclear pore complex. Curr Opin Cell Biol 19(3):305-310
       |ASM4 |CDC31 |DBP5 |GAL1 |GFD1 |GLE1 |GLE2 |HSP104 |HTZ1 |INO1 |KAP120 |KAP122 |KAP123 |KAP95 |MORE
Cellular Location
Function/Process
Genetic Interactions
Mutants/Phenotypes
Protein-protein Interactions
Strains/Constructs
Araki Y, et al. (2006) The Saccharomyces cerevisiae spindle pole body (SPB) component Nbp1p is required for SPB membrane insertion and interacts with the integral membrane proteins Ndc1p and Mps2p. Mol Biol Cell 17(4):1959-70
       |BBP1 |CDC31 |MPS1 |MPS2 |MPS3 |NBP1 |SPC110 |SPC42
Evolution
Fungal Related Genes/Proteins
De Hertogh B, et al. (2006) Emergence of species-specific transporters during evolution of the hemiascomycete phylum. Genetics 172(2):771-81
       |AAC1 |AAC3 |ACS2 |ADP1 |ADY2 |AGC1 |AGP1 |AGP2 |AGP3 |ALP1 |ALR1 |ALR2 |ANT1 |AQR1 |MORE
Computational analysis
Non-Fungal Related Genes/Proteins
Protein Sequence Features
Protein/Nucleic Acid Structure
Strains/Constructs
Devos D, et al. (2006) Simple fold composition and modular architecture of the nuclear pore complex. Proc Natl Acad Sci U S A 103(7):2172-7
       |ASM4 |NIC96 |NSP1 |NUP1 |NUP100 |NUP116 |NUP120 |NUP133 |NUP145 |NUP157 |NUP159 |NUP170 |NUP188 |NUP192 |MORE
Cellular Location
Function/Process
Non-Fungal Related Genes/Proteins
Protein Sequence Features
Lau CK, et al. (2006) Topology of yeast Ndc1p: predictions for the human NDC1/NET3 homologue. Anat Rec A Discov Mol Cell Evol Biol 288(7):681-94

Function/Process
Genetic Interactions
Mutants/Phenotypes
Strains/Constructs
Madrid AS, et al. (2006) The role of the integral membrane nucleoporins Ndc1p and Pom152p in nuclear pore complex assembly and function. J Cell Biol 173(3):361-71
       |ASM4 |NPL3 |NUP159 |NUP60 |POM152 |POM34
Non-Fungal Related Genes/Proteins
Mansfeld J, et al. (2006) The conserved transmembrane nucleoporin NDC1 is required for nuclear pore complex assembly in vertebrate cells. Mol Cell 22(1):93-103

Non-Fungal Related Genes/Proteins
Stavru F, et al. (2006) NDC1: a crucial membrane-integral nucleoporin of metazoan nuclear pore complexes. J Cell Biol 173(4):509-19

Function/Process
Genetic Interactions
Mutants/Phenotypes
Strains/Constructs
Lau CK, et al. (2004) A novel allele of Saccharomyces cerevisiae NDC1 reveals a potential role for the spindle pole body component Ndc1p in nuclear pore assembly. Eukaryot Cell 3(2):447-58
       |NIC96 |NUP49
Protein Physical Properties
Protein Sequence Features
Denning DP, et al. (2003) Disorder in the nuclear pore complex: the FG repeat regions of nucleoporins are natively unfolded. Proc Natl Acad Sci U S A 100(5):2450-5
         |ASM4 |CDC31 |GLE1 |GLE2 |NIC96 |NSP1 |NUP1 |NUP100 |NUP116 |NUP120 |NUP133 |NUP145 |NUP157 |NUP159 |MORE
Cellular Location
Genetic Interactions
Mutants/Phenotypes
Strains/Constructs
McBratney S and Winey M (2002) Mutant membrane protein of the budding yeast spindle pole body is targeted to the endoplasmic reticulum degradation pathway. Genetics 162(2):567-78
       |CUE1 |HRD1 |MPS2 |UBC6 |UBC7
Cellular Location
Genetic Interactions
Strains/Constructs
Marelli M, et al. (2001) A link between the synthesis of nucleoporins and the biogenesis of the nuclear envelope. J Cell Biol 153(4):709-24
       |ASM4 |NUP170 |NUP53 |POM152 |PSE1
Reviews
Vasu SK and Forbes DJ (2001) Nuclear pores and nuclear assembly. Curr Opin Cell Biol 13(3):363-75
       |ASM4 |CDC31 |GLE1 |GLE2 |MLP1 |MLP2 |NIC96 |NSP1 |NUP1 |NUP100 |NUP116 |NUP120 |NUP133 |NUP145 |MORE
Reviews
Adams IR and Kilmartin JV (2000) Spindle pole body duplication: a model for centrosome duplication? Trends Cell Biol 10(8):329-35
       |BBP1 |CDC31 |CMD1 |CNM67 |KAR1 |MPS2 |NUD1 |SPC110 |SPC29 |SPC42 |SPC72 |SPC97 |SPC98 |TUB4
Genetic Interactions
Mutants/Phenotypes
Strains/Constructs
Chial HJ, et al. (2000) Yeast Eap1p, an eIF4E-associated protein, has a separate function involving genetic stability. Curr Biol 10(23):1519-22
       |CDC33 |EAP1
Cellular Location
Protein Physical Properties
Strains/Constructs
Techniques and Reagents
Rout MP, et al. (2000) The yeast nuclear pore complex: composition, architecture, and transport mechanism. J Cell Biol 148(4):635-51
       |AIM4 |ASM4 |BMS1 |BUD20 |CTR9 |GLE1 |GLE2 |HAS1 |KAP120 |KAP122 |KAP123 |KAP95 |KRR1 |MEX67 |MORE
Function/Process
Mutants/Phenotypes
Strains/Constructs
Chial HJ, et al. (1999) Altered dosage of the Saccharomyces cerevisiae spindle pole body duplication gene, NDC1, leads to aneuploidy and polyploidy. Proc Natl Acad Sci U S A 96(18):10200-5

Cellular Location
Function/Process
Genetic Interactions
Mutants/Phenotypes
Strains/Constructs
Techniques and Reagents
Chial HJ, et al. (1998) Saccharomyces cerevisiae Ndc1p is a shared component of nuclear pore complexes and spindle pole bodies. J Cell Biol 143(7):1789-800
       |NUP49 |POM152 |SPC42
Fungal Related Genes/Proteins
West RR, et al. (1998) cut11(+): A gene required for cell cycle-dependent spindle pole body anchoring in the nuclear envelope and bipolar spindle formation in Schizosaccharomyces pombe. Mol Biol Cell 9(10):2839-55

Reviews
Sobel SG (1997) Mini review: mitosis and the spindle pole body in Saccharomyces cerevisiae. J Exp Zool 277(2):120-38
       |CDC31 |CIK1 |DYN1 |KAR1 |KAR3 |MPS1 |MPS2 |NUM1 |SPC110 |SPC42 |TUB1 |TUB2 |TUB4
Reviews
Winsor B and Schiebel E (1997) Review: an overview of the Saccharomyces cerevisiae microtubule and microfilament cytoskeleton. Yeast 13(5):399-434
       |ASE1 |BBP1 |BIK1 |BIM1 |CAP1 |CAP2 |CBC2 |CDC31 |CEN3 |CEN5 |CNM67 |DSK2 |DYN1 |DYN2 |MORE
Reviews
Winey M and Byers B (1993) Assembly and functions of the spindle pole body in budding yeast. Trends Genet 9(9):300-4
     |CDC31 |CIK1 |CIN8 |KAR1 |MPS1 |SPC110 |SPC42 |SPC98
Cell Cycle Phase Involved
Cellular Location
Function/Process
Mutants/Phenotypes
Protein Physical Properties
Protein Sequence Features
Strains/Constructs
Techniques and Reagents
Winey M, et al. (1993) NDC1: a nuclear periphery component required for yeast spindle pole body duplication. J Cell Biol 122(4):743-51
     |CDC34
Cell Cycle Phase Involved
Function/Process
Mutants/Phenotypes
Strains/Constructs
Thomas JH and Botstein D (1986) A gene required for the separation of chromosomes on the spindle apparatus in yeast. Cell 44(1):65-76
       |CCS1 |RAD52

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