Polupanov AS and Sibirny AA (2013) Cytoplasmic extension peptide of Pichia pastoris glucose sensor Gss1 is not compulsory required for glucose signaling. Cell Biol Int ()
Abstract: In the methylotrophic yeast Pichia pastoris, Gss1 protein is a glucose sensor involved in pexophagy, glucose utilization and glucose catabolite repression. This study identifies that deletion of 150 residues of Gss1 slightly affects glucose catabolite repression and pexophagy, still maintaining signaling function of Gss1. At the same time, substitution of one conserved amino acid R180K of Gss1 protein has no visible phenotype, in contrast to corresponding changes in glucose sensors from other yeast species. We suggest that C-terminal cytoplasmic extension of PpGss1 plays different role to that of its homologs in Saccharomyces cerevisiae and Hansenula polymorpha.
|Status: Epub ahead of print||Type: Journal Article||PubMed ID: 24123705|
Topics addressed in this paper
Number of different genes curated to this paper: 2
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