Stumpf JD and Copeland WC (2013) The Exonuclease Activity of the Yeast Mitochondrial DNA Polymerase ? Suppresses Mitochondrial DNA Deletions Between Short Direct Repeats in Saccharomyces cerevisiae. Genetics 194(2):519-22
Abstract: The importance of mitochondrial DNA (mtDNA) deletions in the progeroid phenotype of exonuclease-deficient DNA polymerase ? mice has been intensely debated. We show that disruption of Mip1 exonuclease activity increases mtDNA deletions 160-fold, whereas disease-associated polymerase variants were mostly unaffected, suggesting that exonuclease activity is vital to avoid deletions during mtDNA replication.
|Status: Published||Type: Journal Article||PubMed ID: 23589460|
Topics addressed in this paper
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