Au WC, et al. (2013) A novel role of the N terminus of budding yeast histone h3 variant cse4 in ubiquitin-mediated proteolysis. Genetics 194(2):513-8
Abstract: Regulating levels of centromeric histone H3 (CenH3) variant is crucial for genome stability. Interaction of Psh1, an E3 ligase, with the C terminus of Cse4 has been shown to contribute to its proteolysis. Here, we demonstrate a role for ubiquitination of the N terminus of Cse4 in regulating Cse4 proteolysis for faithful chromosome segregation and a role for Doa1 in ubiquitination of Cse4.
|Status: Published||Type: Journal Article||PubMed ID: 23525333|
Topics addressed in this paper
Number of different genes curated to this paper: 6
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