Reitman ZJ, et al. (2012) Enzyme redesign guided by cancer-derived IDH1 mutations. Nat Chem Biol 8(11):887-9
Abstract: Mutations in an enzyme can result in a neomorphic catalytic activity in cancers. We applied cancer-associated mutations from isocitrate dehydrogenases to homologous residues in the active sites of homoisocitrate dehydrogenases to derive enzymes that catalyze the conversion of 2-oxoadipate to (R)-2-hydroxyadipate, a critical step for adipic acid production. Thus, we provide a prototypic example of how insights from cancer genome sequencing and functional studies can aid in enzyme redesign.
|Status: Published||Type: Journal Article | Research Support, N.I.H., Extramural||PubMed ID: 23001033|
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