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Chen Y, et al. (2013) Establishing a platform cell factory through engineering of yeast acetyl-CoA metabolism. Metab Eng 15():48-54
Abstract: Production of fuels and chemicals by industrial biotechnology requires efficient, safe and flexible cell factory platforms that can be used for production of a wide range of compounds. Here we developed a platform yeast cell factory for efficient provision of acetyl-CoA that serves as precursor metabolite for a wide range of industrially interesting products. We demonstrate that the platform cell factory can be used to improve the production of alpha-santalene, a plant sesquiterpene that can be used as a perfume by four-fold. This strain would be a useful tool to produce a wide range of acetyl-CoA-derived products.
| Status: Published | Type: Journal Article | Research Support, Non-U.S. Gov't | PubMed ID: 23164578 |
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