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Nagamori E, et al.  (2012) Metabolic flux analysis of genetically engineered Saccharomyces cerevisiae that produces lactate under micro-aerobic conditions. Bioprocess Biosyst Eng ()

Abstract: In the present study, to elucidate mechanisms of growth suppression in YIBO-pdc1/5Delta, we performed carbon metabolic flux analysis under micro-aerobic conditions. Our results indicate that growth suppression of YIBO-pdc1/5Delta is caused by decreased flux to the pentose phosphate pathway, which supplies ribose-5-phosphate, a precursor for histidine synthesis in Sacchar omyces cerevisiae. In addition, significant accumulation of pyruvate was observed in the continuous culture.

Status: Epub ahead of print

Type: Journal Article

PubMed ID: 23223911

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Nagamori E Shimizu K Fujita H Tokuhiro K Ishida N Takahashi H Papers in SGD Colleagues in SGD PubMed Google Scholar

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