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Zou L  (2013) Four pillars of the S-phase checkpoint. Genes Dev 27(3):227-33

Abstract: The yeast Mec1 kinase is a key regulator of the DNA damage response (DDR). In this issue of Genes & Development, Kumar and Burgers (pp. 313-321) report that Ddc1, Dpb11, and Dna2 function in concert to activate Mec1 during S phase of the cell cycle. Furthermore, the Tel1 kinase also contributes to the DDR in S phase when Mec1 activation is compromised.

Status: Published Type: Journal Article PubMed ID: 23388823

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