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Miller C, et al.  (2012) Mediator phosphorylation prevents stress response transcription during non-stress conditions. J Biol Chem 287(53):44017-26

Abstract: The multiprotein complex Mediator is a coactivator of RNA polymerase (Pol) II transcription that is required for the regulated expression of protein-coding genes. Mediator serves as an end point of signaling pathways and regulates Pol II transcription, but the mechanisms it uses are not well understood. Here, we used mass spectrometry and dynamic transcriptome analysis to investigate a functional role of Mediator phosphorylation in gene expression. Affinity purification and mass spectrometry revealed that Mediator from the yeast Saccharomyces cerevisiae is phosphorylated at multiple sites of 17 of its 25 subunits. Mediator phosphorylation levels change upon an external stimulus set by exposure of cells to high salt concentrations. Phosphorylated sites in the Mediator tail subunit Med15 are required for suppression of stress-induced changes in gene expression under non-stress conditions. Thus dynamic and differential Mediator phosphorylation contributes to gene regulation in eukaryotic cells.

Status: Published Type: Journal Article PubMed ID: 23135281

Topics addressed in this paper

Number of different genes curated to this paper: 54

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ADA2 CHD1 CSE2 DDR2 FHL1 GAL11 GCN5 GSY1 GSY2 HFI1
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HOG1 HSP12 LEU3 MED1 MED11 MED2 MED4 MED6 MED7 MED8
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NGG1 NUT1 NUT2 PGD1 RAP1 RGR1 ROX3 SGF11 SGF29 SGF73
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Topics Genes linked to topics (#31 - 40 )
SIN4 SOH1 SOK2 SPT20 SPT3 SPT7 SPT8 SRB2 SRB4 SRB5
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SRB6 SRB8 SSN2 SSN3 SSN8 SUS1 TAF10 TAF12 TAF14 TAF5
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Topics Genes linked to topics (#51 - 54 )
TAF6 TAF9 TRA1 UBP8
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