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Rachfall N, et al.  (2013) RACK1/Asc1p, a ribosomal node in cellular signaling. Mol Cell Proteomics 12(1):87-105

Abstract: RACK1/Asc1p and its essential orthologues in higher eukaryotes, such as RACK1 in metazoa, are involved in several distinct cellular signaling processes. The implications of a total deletion have never been assessed in a comprehensive manner. This study reveals the major cellular processes affected in a Saccharomyces cerevisiae ?asc1 deletion background via de novo proteome and transcriptome analysis, as well as subsequent phenotypical characterizations. The deletion of ASC1 reduces iron uptake and causes nitrosative stress, both known indicators for hypoxia, which manifests in a shift of energy metabolism from respiration to fermentation in the ?asc1 strain. Asc1p further impacts cellular metabolism through its regulative role in the MAP kinase signal transduction pathways of invasive/filamentous growth and cell wall integrity. In the ?asc1 mutant strain, aberrations from the expected cellular response, mediated by these pathways, can be observed and are linked to changes in protein abundances of pathway-targeted transcription factors. Evidence of the translational regulation of such transcription factors suggests that ribosomal Asc1p is involved in signal transduction pathways and controls the biosynthesis of the respective final transcriptional regulators.

Status: Published Type: Journal Article PubMed ID: 23071099

Topics addressed in this paper

Number of different genes curated to this paper: 54

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
ADH1 AHP1 ARN1 ASC1 ATP1 ATP2 CCC2 CDC19 CWP2 DDR2
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Topics Genes linked to topics (#11 - 20 )
DID2 ENB1 ENO1 ENO2 FBA1 FET3 FLO11 FLO8 FRE1 FTR1
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Topics Genes linked to topics (#21 - 30 )
GPM1 GUK1 HBN1 HOR2 HOR7 HPF1 HXT3 HXT6 HXT7 INH1
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Topics Genes linked to topics (#31 - 40 )
IRC18 MDH1 PDC1 PDC5 PDI1 PEP4 PGI1 PHD1 PSA1 RAP1
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Topics Genes linked to topics (#41 - 50 )
RDL1 RHR2 RIB4 SCW4 SIT1 SSC1 STE12 TEC1 TIS11 TPI1
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Topics Genes linked to topics (#51 - 54 )
TSA1 UTR2 WSC3 YHB1
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