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Strunk BS, et al.  (2012) A translation-like cycle is a quality control checkpoint for maturing 40S ribosome subunits. Cell 150(1):111-21

Abstract: Assembly factors (AFs) prevent premature translation initiation on small (40S) ribosomal subunit assembly intermediates by blocking ligand binding. However, it is unclear how AFs are displaced from maturing 40S ribosomes, if or how maturing subunits are assessed for fidelity, and what prevents premature translation initiation once AFs dissociate. Here we show that maturation involves a translation-like cycle whereby the translation factor eIF5B, a GTPase, promotes joining of large (60S) subunits with pre-40S subunits to give 80S-like complexes, which are subsequently disassembled by the termination factor Rli1, an ATPase. The AFs Tsr1 and Rio2 block the mRNA channel and initiator tRNA binding site, and therefore 80S-like ribosomes lack mRNA or initiator tRNA. After Tsr1 and Rio2 dissociate from 80S-like complexes Rli1-directed displacement of 60S subunits allows for translation initiation. This cycle thus provides a functional test of 60S subunit binding and the GTPase site before ribosomes enter the translating pool.CI - Copyright (c) 2012 Elsevier Inc. All rights reserved.

Status: Published Type: Journal Article | Research Support, N.I.H., Extramural | Research Support, U.S. Gov't, Non-P.H.S. PubMed ID: 22770215

Topics addressed in this paper

Number of different genes curated to this paper: 61

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Topics Genes linked to topics (#1 - 10 )
ANB1 ASC1 BMH2 DIM1 DOM34 EFB1 ENP1 FAP7 FUN12 HYP2
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Topics Genes linked to topics (#11 - 20 )
IMT1 IMT2 IMT3 IMT4 LTV1 NOB1 OLA1 PNO1 RIO2 RLI1
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Topics Genes linked to topics (#21 - 30 )
RLP7 RPL11A RPL11B RPL12A RPL12B RPL14A RPL14B RPL23A RPL23B RPL26A
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Topics Genes linked to topics (#31 - 40 )
RPL26B RPL5 RPL6A RPL6B RPP0 RPS0A RPS0B RPS10A RPS10B RPS12
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Topics Genes linked to topics (#41 - 50 )
RPS13 RPS14A RPS14B RPS16A RPS16B RPS18A RPS18B RPS22A RPS22B RPS26A
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Topics Genes linked to topics (#51 - 60 )
RPS7A RPS7B SAM1 SUI1 TEF1 TEF2 TIF1 TIF2 TSA1 TSR1
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Topics Genes linked to topics (#61 )
VMA4
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