Frassinetti S, et al. (2012) Antimutagenic and antioxidant activity of Lisosan G in Saccharomyces cerevisiae. Food Chem 135(3):2029-34
Abstract: In the present study the antimutagenic and antioxidant effects of a powder of grain (Lisosan G) in yeast Saccharomyces cerevisiae were studied. Results showed that Lisosan G treatment decreased significantly the intracellular ROS concentration and mutagenesis induced by hydrogen peroxide in S. cerevisiae D7 strain. The effect of Lisosan G was then evaluated by using superoxide dismutase (SOD) proficient and deficient strains of S. cerevisiae. Lisosan G showed protective activity in sod1Delta and sod2Delta mutant strains, indicating an in vivo antioxidant effect. A high radical scavenging activity of Lisosan G was also demonstrated in vitro using the oxygen radical absorbance capacity (ORAC) assay. The obtained results showed a protective effect of Lisosan G in yeast cells, indicating that its antioxidant capacity contributes to its antimutagenic action.CI - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
|Status: Published||Type: Journal Article||PubMed ID: 22953954|
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