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Frey AG and Eide DJ  (2012) Zinc-responsive coactivator recruitment by the yeast Zap1 transcription factor. Microbiologyopen 1(2):105-14

Abstract: The zinc-responsive Zap1 transcription factor of Saccharomyces cerevisiae controls many genes involved in zinc homeostasis. Zap1 has two activation domains, AD1 and AD2, which are independently regulated by zinc. While AD1 can fully activate most Zap1 target genes, AD2 is active only on a subset of those genes. One hypothesis explaining this promoter specificity was that AD1 and AD2 recruit different coactivators. To address this question, we carried out a genetic screen to identify coactivator complexes that are required for Zap1-mediated activation. SWI/SNF, SAGA, and Mediator complexes were implicated as playing major roles in Zap1 activation. Consistent with this conclusion, we found that these three complexes are recruited to Zap1 target promoters in a zinc-responsive and Zap1-dependent manner. Coactivator recruitment was highly interdependent such that mutations disrupting SAGA impaired recruitment of SWI/SNF and vice versa. Optimal Mediator recruitment was dependent on both SAGA and SWI/SNF. A comparison of the coactivators recruited by AD1 and AD2 found no obvious differences suggesting that recruitment of different coactivators is not likely the mechanism of AD specificity. Rather, our results suggest that AD2 recruits coactivators less effectively than AD1 and is therefore only functional on some promoters.

Status: Published Type: Journal Article PubMed ID: 22950018

Topics addressed in this paper

Number of different genes curated to this paper: 62

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Topics Genes linked to topics (#1 - 10 )
ADA2 AHC1 AYT1 BDF1 BDF2 CAF130 CAF16 CAF4 CAF40 CCR4
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Topics Genes linked to topics (#11 - 20 )
CDC73 CHD1 DHH1 DPP1 DST1 EAF3 ELP3 GAL11 HFI1 HPA2
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Topics Genes linked to topics (#21 - 30 )
HPA3 HPR1 ISW1 ISW2 ITC1 LEO1 MED1 MFT1 MOT2 NGG1
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Topics Genes linked to topics (#31 - 40 )
NOT3 NOT5 NUT1 PAF1 PGD1 POP2 RSC1 RSC2 RTF1 SAS2
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Topics Genes linked to topics (#41 - 50 )
SAS3 SIN4 SNF1 SNF2 SNF5 SNF6 SPT20 SPT3 SPT7 SPT8
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Topics Genes linked to topics (#51 - 60 )
SRB2 SRB8 SSN3 SSN8 SWI3 TAF14 TEX1 THP2 TPA1 YOR387C
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Topics Genes linked to topics (#61 - 62 )
ZAP1 ZRT1
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