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Bock LJ, et al.  (2012) Cnn1 inhibits the interactions between the KMN complexes of the yeast kinetochore. Nat Cell Biol 14(6):614-24

Abstract: Kinetochores attach the replicated chromosomes to the mitotic spindle and orchestrate their transmission to the daughter cells. Kinetochore-spindle binding and chromosome segregation are mediated by the multi-copy KNL1(Spc105), MIS12(Mtw1) and NDC80(Ndc80) complexes that form the so-called KMN network. KMN-spindle attachment is regulated by the Aurora B(Ipl1) and MPS1(Mps1) kinases. It is unclear whether other mechanisms exist that support KMN activity during the cell cycle. Using budding yeast, we show that kinetochore protein Cnn1 localizes to the base of the Ndc80 complex and promotes a functionally competent configuration of the KMN network. Cnn1 regulates KMN activity in a spatiotemporal manner by inhibiting the interaction between its complexes. Cnn1 activity peaks in anaphase and is driven by the Cdc28, Mps1 and Ipl1 kinases.

Status: Published Type: Journal Article | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't PubMed ID: 22561345

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Topics Genes linked to topics (#1 - 10 )
AME1 BIK1 CBF2 CHL4 CNN1 CSE4 DAM1 DUO1 IML3 IPL1
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Topics Genes linked to topics (#11 - 20 )
MCD1 MIF2 MPS1 MTW1 NNF1 OKP1 SGT1 SPC24 SPC25 STU2
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Topics Genes linked to topics (#21 - 24 )
TID3 TOP2 TUB1 TUB2
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