SGD Paper Help


Page Contents:
Smolle M, et al.  (2012) Chromatin remodelers Isw1 and Chd1 maintain chromatin structure during transcription by preventing histone exchange. Nat Struct Mol Biol 19(9):884-92

Abstract: Set2-mediated methylation of histone H3 Lys36 (H3K36) is a mark associated with the coding sequences of actively transcribed genes, but it has a negative role during transcription elongation. It prevents trans-histone exchange over coding regions and signals for histone deacetylation in the wake of RNA polymerase II (RNAPII) passage. We have found that in Saccharomyces cerevisiae the Isw1b chromatin-remodeling complex is specifically recruited to open reading frames (ORFs) by H3K36 methylation through the PWWP domain of its Ioc4 subunit in vivo and in vitro. Isw1b acts in conjunction with Chd1 to regulate chromatin structure by preventing trans-histone exchange from taking place over coding regions. In this way, Isw1b and Chd1 are important in maintaining chromatin integrity during transcription elongation by RNAPII.

Status: Published Type: Journal Article PubMed ID: 22922743

Topics addressed in this paper

Number of different genes curated to this paper: 45

Jump to Summary Chart for:
  • To find other papers on a gene and topic, click on the colored ball in the appropriate box.
  • displays other papers with information about that topic for that gene.
  • displays other papers in SGD that are associated with that topic.
    The topic is addressed in these papers but does not describe a specific gene or chromosomal feature.
  • To go to the Locus page for a gene, click on the gene name.
Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
CHD1 DEP1 DPB4 EAF3 HHF1 HHF2 HHO1 HHT1 HHT2 HIR1
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Function/Process blue ball
Genetic Interactions blue ball
Genomic co-immunoprecipitation study blue ball blue ball
Genomic expression study yg ball
Mutants/Phenotypes blue ball
Omics yg ball
Primary Literature blue ball blue ball blue ball
Protein Processing/Modification/Regulation blue ball blue ball blue ball blue ball
Protein-protein Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Regulatory Role blue ball blue ball
Strains/Constructs blue ball
Techniques and Reagents blue ball blue ball

Topics Genes linked to topics (#11 - 20 )
HIR2 HIR3 HTA1 HTA2 HTB1 HTB2 IOC2 IOC3 IOC4 ISW1
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Cellular Location blue ball blue ball
Function/Process blue ball
Genetic Interactions blue ball
Mutants/Phenotypes blue ball blue ball
Primary Literature blue ball blue ball blue ball
Protein Sequence Features blue ball blue ball
Protein-Nucleic Acid Interactions blue ball blue ball
Protein-protein Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Strains/Constructs blue ball blue ball

Topics Genes linked to topics (#21 - 30 )
ISW2 ITC1 PCA1 POB3 RCO1 RPB10 RPB11 RPB2 RPB3 RPB4
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Mutants/Phenotypes blue ball
Protein-protein Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Strains/Constructs blue ball
Transcription blue ball
Jump to Summary Chart for:
  • To find other papers on a gene and topic, click on the colored ball in the appropriate box.
  • displays other papers with information about that topic for that gene.
  • displays other papers in SGD that are associated with that topic.
    The topic is addressed in these papers but does not describe a specific gene or chromosomal feature.
  • To go to the Locus page for a gene, click on the gene name.

Topics Genes linked to topics (#31 - 40 )
RPB5 RPB7 RPB8 RPB9 RPC10 RPD3 RPO21 RPO26 RTT106 SET2
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Mutants/Phenotypes blue ball
Primary Literature blue ball
Protein-protein Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Strains/Constructs blue ball

Topics Genes linked to topics (#41 - 45 )
SIN3 SPT16 SPT6 STE11 UME1
Additional Literature blue ball blue ball blue ball blue ball blue ball
Protein-protein Interactions blue ball blue ball blue ball blue ball
Transcription blue ball

Author Searches

To find contact information or other publications by the authors of this paper, follow these three steps:
  1. (1) Choose an author,
  2. (2) Choose a search parameter,
  3. (3) Click to implement
Page Contents: