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Suzuki T and Iwahashi Y  (2012) Comprehensive gene expression analysis of type B trichothecenes. J Agric Food Chem 60(37):9519-27

Abstract: Type B trichothecenes, deoxynivalenol (DON) and nivalenol (NIV), are secondary metabolites of Fusarium species and are major pollutants in food and feed products. Recently, the production trend of their derivatives, 3-acetyldeoxynivalenol (3-AcDON), 15-acetyldeoxynivalenol (15-AcDON), and 4-acetylnivalenol (4-AcNIV or fusarenon-X), has been changing in various regions worldwide. Although in vivo behavior has been reported, it is necessary to acquire more detailed information about these derivatives. Here, the yeast PDR5 mutant was used for toxicity evaluation, and the growth test revealed that DON, 15-AcDON, and 4-AcNIV had higher toxicity compared to 3-AcDON and NIV. 15-AcDON exerted the most significant gene expression changes, and cellular localization clustering exhibited repression of mitochondrial ribosomal genes. This study suggests that the toxicity trends of both DON products (DON and its derivatives) and NIV products (NIV and its derivatives) are similar to those observed in mammalian cells, with a notable toxic response to 15-AcDON.

Status: Published Type: Journal Article PubMed ID: 22897823

Topics addressed in this paper

Number of different genes curated to this paper: 32

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
AQR1 AZR1 DTR1 FLR1 HXT11 HXT12 HXT9 IPT1 PDR1 PDR10
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Topics Genes linked to topics (#11 - 20 )
PDR15 PDR3 PDR5 PDR8 PLB1 PUG1 RSB1 RTA1 SFK1 SNG1
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Genomic expression study blue ball
Industrial Applications blue ball blue ball
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Topics Genes linked to topics (#21 - 30 )
SNQ2 TPO1 TPO2 TPO4 YHK8 YLL056C YLR046C YLR179C YLR346C YMR102C
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Topics Genes linked to topics (#31 - 32 )
YPL088W YRR1
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