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Richardson LA, et al.  (2012) A conserved deubiquitinating enzyme controls cell growth by regulating RNA polymerase I stability. Cell Rep 2(2):372-85

Abstract: Eukaryotic ribosome biogenesis requires hundreds of trans-acting factors and dozens of RNAs. Although most factors required for ribosome biogenesis have been identified, little is known about their regulation. Here, we reveal that the yeast deubiquitinating enzyme Ubp10 is localized to the nucleolus and that ubp10? cells have reduced pre-rRNAs, mature rRNAs, and translating ribosomes. Through proteomic analyses, we found that Ubp10 interacts with proteins that function in rRNA production and ribosome biogenesis. In particular, we discovered that the largest subunit of RNA polymerase I (RNAPI) is stabilized via Ubp10-mediated deubiquitination and that this is required in order to achieve optimal levels of ribosomes and cell growth. USP36, the human ortholog of Ubp10, complements the ubp10? allele for RNAPI stability, pre-rRNA processing, and cell growth in yeast, suggesting that deubiquitination of RNAPI may be conserved in eukaryotes. Our work implicates Ubp10/USP36 as a key regulator of rRNA production through control of RNAPI stability.

Status: Published Type: Journal Article PubMed ID: 22902402

Topics addressed in this paper

Number of different genes curated to this paper: 39

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Topics Genes linked to topics (#1 - 10 )
CBF5 CKA1 CKA2 CKB1 CKB2 DBP2 DHR2 DIP2 DPB4 HAS1
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein-protein Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#11 - 20 )
HTB2 NAN1 NOP56 NOP58 PRP43 PWP2 RDN18-1 RDN18-2 RDN25-1 RDN25-2
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein-protein Interactions blue ball blue ball blue ball blue ball blue ball blue ball
Regulation of blue ball blue ball blue ball blue ball
RNA Levels and Processing blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#21 - 30 )
RDN37-1 RDN37-2 RPA190 RRP7 SIR2 SIR4 UBP10 UBP8 UTP10 UTP13
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Cellular Location blue ball
Cross-species Expression blue ball
Function/Process blue ball
Genetic Interactions blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball
Non-Fungal Related Genes/Proteins blue ball
Primary Literature blue ball blue ball
Protein Processing/Modification/Regulation blue ball
Protein Sequence Features blue ball
Protein-protein Interactions blue ball blue ball blue ball blue ball blue ball
Regulation of blue ball blue ball blue ball
Regulatory Role blue ball
RNA Levels and Processing blue ball blue ball
Strains/Constructs blue ball blue ball blue ball blue ball blue ball
Substrates/Ligands/Cofactors blue ball
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Topics Genes linked to topics (#31 - 39 )
UTP15 UTP18 UTP21 UTP22 UTP4 UTP5 UTP6 UTP8 UTP9
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein-protein Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

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