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Jakovljevic J, et al.  (2012) Ribosomal proteins L7 and L8 function in concert with six A3 assembly factors to propagate assembly of domains I and II of 25S rRNA in yeast 60S ribosomal subunits. RNA 18(10):1805-22

Abstract: Ribosome biogenesis is a complex multistep process that involves alternating steps of folding and processing of pre-rRNAs in concert with assembly of ribosomal proteins. Recently, there has been increased interest in the roles of ribosomal proteins in eukaryotic ribosome biogenesis in vivo, focusing primarily on their function in pre-rRNA processing. However, much less is known about participation of ribosomal proteins in the formation and rearrangement of preribosomal particles as they mature to functional subunits. We have studied ribosomal proteins L7 and L8, which are required for the same early steps in pre-rRNA processing during assembly of 60S subunits but are located in different domains within ribosomes. Depletion of either leads to defects in processing of 27SA(3) to 27SB pre-rRNA and turnover of pre-rRNAs destined for large ribosomal subunits. A specific subset of proteins is diminished from these residual assembly intermediates: six assembly factors required for processing of 27SA(3) pre-rRNA and four ribosomal proteins bound to domain I of 25S and 5.8S rRNAs surrounding the polypeptide exit tunnel. In addition, specific sets of ribosomal proteins are affected in each mutant: In the absence of L7, proteins bound to domain II, L6, L14, L20, and L33 are greatly diminished, while proteins L13, L15, and L36 that bind to domain I are affected in the absence of L8. Thus, L7 and L8 might establish RNP structures within assembling ribosomes necessary for the stable association and function of the A(3) assembly factors and for proper assembly of the neighborhoods containing domains I and II.

Status: Published Type: Journal Article PubMed ID: 22893726

Topics addressed in this paper

Number of different genes curated to this paper: 99

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Topics Genes linked to topics (#1 - 10 )
AFG2 ARX1 BRX1 CGR1 CIC1 DBP10 DBP3 DBP6 DRS1 EBP2
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Topics Genes linked to topics (#11 - 20 )
ECM1 ERB1 HAS1 JJJ1 LOC1 MAK16 MRT4 NIP7 NMD3 NOG1
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Topics Genes linked to topics (#21 - 30 )
NOG2 NOP15 NOP16 NOP2 NOP7 NSA1 NSA2 NUG1 RDN25-1 RDN25-2
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Topics Genes linked to topics (#31 - 40 )
RDN37-1 RDN37-2 RDN5-1 RDN5-2 RDN5-3 RDN5-4 RDN5-5 RDN5-6 RDN58-1 RDN58-2
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Topics Genes linked to topics (#41 - 50 )
REH1 REI1 RIX7 RLP24 RLP7 RPF1 RPF2 RPL10 RPL11A RPL11B
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Topics Genes linked to topics (#51 - 60 )
RPL12A RPL12B RPL13A RPL13B RPL14A RPL14B RPL15A RPL15B RPL16A RPL16B
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Topics Genes linked to topics (#61 - 70 )
RPL17A RPL17B RPL18A RPL18B RPL19A RPL19B RPL20A RPL20B RPL21A RPL21B
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Topics Genes linked to topics (#71 - 80 )
RPL26A RPL26B RPL28 RPL33A RPL33B RPL35A RPL35B RPL36A RPL36B RPL37A
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Topics Genes linked to topics (#81 - 90 )
RPL37B RPL6A RPL6B RPL7A RPL7B RPL8A RPL8B RPP0 RRP1 RRP15
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Topics Genes linked to topics (#91 - 99 )
RRS1 RSA3 SDO1 SPB1 SQS1 TIF6 YBL028C YTM1 YVH1
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