Reggiori F and Tooze SA (2012) Autophagy regulation through Atg9 traffic. J Cell Biol 198(2):151-3
Abstract: Rapid membrane expansion is the key to autophagosome formation during nutrient starvation. In this issue, Yamamoto et al. (2012. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201202061) now provide a mechanism for vesicle-mediated initiation of autophagosome biogenesis. They show that Atg9 vesicles, produced de novo during starvation, are approximately 30-60 nm in size and contain approximately 30 molecules of Atg9. These vesicles assemble to form an autophagosome, and subsequently, the Atg9 embedded in the outer membrane is recycled to avoid degradation.
|Status: Published||Type: Comment | Journal Article | Research Support, Non-U.S. Gov't||PubMed ID: 22826119|
Topics addressed in this paper
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