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Ha SW, et al.  (2012) The N-terminal domain of Rpn4 serves as a portable ubiquitin-independent degron and is recognized by specific 19S RP subunits. Biochem Biophys Res Commun 419(2):226-31

Abstract: The number of proteasomal substrates that are degraded without prior ubiquitylation continues to grow. However, it remains poorly understood how the proteasome recognizes substrates lacking a ubiquitin (Ub) signal. Here we demonstrated that the Ub-independent degradation of Rpn4 requires the 19S regulatory particle (RP). The Ub-independent degron of Rpn4 was mapped to an N-terminal region including the first 80 residues. Inspection of its amino acid sequence revealed that the Ub-independent degron of Rpn4 consists of an intrinsically disordered domain followed by a folded segment. Using a photo-crosslinking-label transfer method, we captured three 19S RP subunits (Rpt1, Rpn2 and Rpn5) that bind the Ub-independent degron of Rpn4. This is the first time that specific 19S RP subunits have been identified interacting with a Ub-independent degron. This study provides insight into the mechanism by which Ub-independent substrates are recruited to the 26S proteasome.CI - Copyright (c) 2012 Elsevier Inc. All rights reserved.

Status: Published Type: Journal Article | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. PubMed ID: 22349505

Topics addressed in this paper

Number of different genes curated to this paper: 47

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Topics Genes linked to topics (#1 - 10 )
BLM10 CIC1 DOA4 ECM29 HUL5 PRE1 PRE10 PRE2 PRE3 PRE4
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Function/Process blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#11 - 20 )
PRE5 PRE6 PRE7 PRE8 PRE9 PUP1 PUP2 PUP3 RAD23 RAD6
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Topics Genes linked to topics (#21 - 30 )
RPN1 RPN10 RPN11 RPN12 RPN13 RPN14 RPN2 RPN3 RPN4 RPN5
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Topics Genes linked to topics (#31 - 40 )
RPN6 RPN7 RPN8 RPN9 RPT1 RPT2 RPT3 RPT4 RPT5 RPT6
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Function/Process blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#41 - 47 )
SCL1 SEM1 UBC1 UBC4 UBC5 UBP6 UMP1
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