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Schleiffer A, et al.  (2012) CENP-T proteins are conserved centromere receptors of the Ndc80 complex. Nat Cell Biol 14(6):604-13

Abstract: Centromeres direct the assembly of kinetochores, microtubule-attachment sites that allow chromosome segregation on the mitotic spindle. Fundamental differences in size and organization between evolutionarily distant eukaryotic centromeres have in many cases obscured general principles of their function. Here we demonstrate that centromere-binding proteins are highly conserved between budding yeast and humans. We identify the histone-fold protein Cnn1(CENP-T) as a direct centromere receptor of the microtubule-binding Ndc80 complex. The amino terminus of Cnn1 contains a conserved peptide motif that mediates stoichiometric binding to the Spc24-25 domain of the Ndc80 complex. Consistent with the critical role of this interaction, artificial tethering of the Ndc80 complex through Cnn1 allows mini-chromosomes to segregate in the absence of a natural centromere. Our results reveal the molecular function of CENP-T proteins and demonstrate how the Ndc80 complex is anchored to centromeres in a manner that couples chromosome movement to spindle dynamics.

Status: Published Type: Journal Article PubMed ID: 22561346

Topics addressed in this paper

Number of different genes curated to this paper: 31

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
AME1 CHL4 CNN1 CSE4 CTF19 CTF3 DSN1 IML3 KRE28 MCM16
Additional Literature blue ball blue ball blue ball
Cell Cycle Phase Involved blue ball
Cellular Location blue ball blue ball blue ball blue ball
Function/Process blue ball
Fungal Related Genes/Proteins blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Genetic Interactions blue ball
Genomic co-immunoprecipitation study yg ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball
Non-Fungal Related Genes/Proteins blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Omics yg ball
Primary Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein Physical Properties blue ball blue ball blue ball blue ball blue ball
Protein Sequence Features blue ball blue ball blue ball
Protein-protein Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Strains/Constructs blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#11 - 20 )
MCM21 MCM22 MHF1 MHF2 MIF2 MPH1 MSH2 MSH3 MTW1 NKP1
Additional Literature blue ball blue ball blue ball
Fungal Related Genes/Proteins blue ball blue ball blue ball blue ball blue ball blue ball
Genetic Interactions blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball
Non-Fungal Related Genes/Proteins blue ball blue ball blue ball blue ball blue ball blue ball
Primary Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein Physical Properties blue ball blue ball blue ball
Protein Sequence Features blue ball
Protein-protein Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Strains/Constructs blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#21 - 30 )
NKP2 NNF1 NSL1 NUF2 OKP1 SPC105 SPC24 SPC25 TID3 WIP1
Additional Literature blue ball blue ball
Alias blue ball
Cell Cycle Phase Involved blue ball blue ball blue ball blue ball
Cellular Location blue ball
Fungal Related Genes/Proteins blue ball blue ball blue ball
Genetic Interactions blue ball
Mutants/Phenotypes blue ball
Non-Fungal Related Genes/Proteins blue ball blue ball
Primary Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein Physical Properties blue ball blue ball blue ball blue ball blue ball blue ball
Protein Sequence Features blue ball blue ball
Protein-protein Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Strains/Constructs blue ball blue ball
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Topics Genes linked to topics (#31 )
YBP2
Additional Literature blue ball
Fungal Related Genes/Proteins blue ball
Non-Fungal Related Genes/Proteins blue ball

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