Cesarini E, et al. (2012) H4K16 acetylation affects recombination and ncRNA transcription at rDNA in Saccharomyces cerevisiae. Mol Biol Cell 23(14):2770-81
Abstract: Transcription-associated recombination is an important process involved in several aspects of cell physiology. In the ribosomal DNA (rDNA) of Saccharomyces cerevisiae, RNA polymerase II transcription-dependent recombination has been demonstrated among the repeated units. In this study, we investigate the mechanisms controlling this process at the chromatin level. On the basis of a small biased screening, we found that mutants of histone deacetylases and chromatin architectural proteins alter both the amount of Pol II-dependent noncoding transcripts and recombination products at rDNA in a coordinated manner. Of interest, chromatin immunoprecipitation analyses in these mutants revealed a corresponding variation of the histone H4 acetylation along the rDNA repeat, particularly at Lys-16. Here we provide evidence that a single, rapid, and reversible posttranslational modification-the acetylation of the H4K16 residue-is involved in the coordination of transcription and recombination at rDNA.
|Status: Published||Type: Journal Article||PubMed ID: 22621897|
Topics addressed in this paper
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|Topics||Topics not linked to Genes||Genes linked to topics (#1 - 10 )|
|Genomic co-immunoprecipitation study|
|Protein Sequence Features|
|Protein-Nucleic Acid Interactions|
|Topics||Genes linked to topics (#11 - 14 )|