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Cap M, et al.  (2012) Cell differentiation within a yeast colony: metabolic and regulatory parallels with a tumor-affected organism. Mol Cell 46(4):436-48

Abstract: Nutrient sensing and metabolic reprogramming are crucial for metazoan cell aging and tumor growth. Here, we identify metabolic and regulatory parallels between a layered, multicellular yeast colony and a tumor-affected organism. During development, a yeast colony stratifies into U and L cells occupying the upper and lower colony regions, respectively. U cells activate a unique metabolism controlled by the glutamine-induced TOR pathway, amino acid-sensing systems (SPS and Gcn4p) and signaling from mitochondria with lowered respiration. These systems jointly modulate U cell physiology, which adapts to nutrient limitations and utilize the nutrients released from L cells. Stress-resistant U cells share metabolic pathways and other similar characteristics with tumor cells, including the ability to proliferate. L cells behave similarly to stressed and starving cells, which activate degradative mechanisms to provide nutrients to U cells. Our data suggest a nutrient flow between both cell types, resembling the Cori cycle and glutamine-NH(4)(+) shuttle between tumor and healthy metazoan cells.

Status: Published Type: Journal Article PubMed ID: 22560924

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ACB1 APN2 ATG1 ATG12 ATG5 ATG8 BAP2 BIO2 BIO3 CAD1
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CAT8 CDC3 CHO1 COA1 DUR3 EFT2 ENO1 FAA1 FCY22 FEN1
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FIS1 FUN26 FUR4 FZO1 GAL83 GCN2 GCV3 GDH3 GIP2 GLN1
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Topics Genes linked to topics (#31 - 40 )
GLT1 GLY1 GND1 GNP1 HAA1 HAC1 HAP5 HSP10 HSP42 HXT3
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HXT4 HYP2 INO1 INO4 IRA2 LCL2 MET17 MSN2 MSN4 MTH1
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NDI1 NVJ1 ODC2 OLE1 OPI1 ORT1 PCK1 PDR15 PDR16 PDR5
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Topics Genes linked to topics (#61 - 70 )
PFK2 PGK1 PHO8 PIG2 PIL1 PLB1 POT1 POX1 PRB1 RDR1
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REG2 RPN4 RSB1 RTG1 SDH1 SHP1 SIP2 SKN7 SNQ2 SNZ1
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SOK2 SSA4 STD1 SUR2 SUR4 SUT1 TAL1 TAT1 TDH1 TKL1
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Topics Genes linked to topics (#91 - 96 )
UGA2 UGA4 USV1 XBP1 YAK1 YMC2
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