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Uluisik I, et al.  (2011) Boron stress activates the general amino acid control mechanism and inhibits protein synthesis. PLoS One 6(11):e27772

Abstract: Boron is an essential micronutrient for plants, and it is beneficial for animals. However, at high concentrations boron is toxic to cells although the mechanism of this toxicity is not known. Atr1 has recently been identified as a boron efflux pump whose expression is upregulated in response to boron treatment. Here, we found that the expression of ATR1 is associated with expression of genes involved in amino acid biosynthesis. These mechanisms are strictly controlled by the transcription factor Gcn4 in response to boron treatment. Further analyses have shown that boron impaired protein synthesis by promoting phosphorylation of eIF2alpha in a Gcn2 kinase dependent manner. The uncharged tRNA binding domain (HisRS) of Gcn2 is necessary for the phosphorylation of eIF2alpha in the presence of boron. We postulate that boron exerts its toxic effect through activation of the general amino acid control system and inhibition of protein synthesis. Since the general amino acid control pathway is conserved among eukaryotes, this mechanism of boron toxicity may be of general importance.

Status: Published

Type: Journal Article | Research Support, Non-U.S. Gov't

PubMed ID: 22114689

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Uluisik I Kaya A Fomenko DE Karakaya HC Carlson BA Gladyshev VN Koc A Papers in SGD Colleagues in SGD PubMed Google Scholar

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