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Spira F, et al.  (2012) Patchwork organization of the yeast plasma membrane into numerous coexisting domains.LID - 10.1038/ncb2487 [doi] Nat Cell Biol ()

Abstract: The plasma membrane is made up of lipids and proteins, and serves as an active interface between the cell and its environment. Many plasma-membrane proteins are laterally segregated in the plane of the membrane, but the underlying mechanisms remain controversial. Here we investigate the distribution and dynamics of a representative set of plasma-membrane-associated proteins in yeast cells. These proteins were distributed non-homogeneously in patterns ranging from distinct patches to nearly continuous networks, and these patterns were in turn strongly influenced by the lipid composition of the plasma membrane. Most proteins segregated into distinct domains. However, proteins with similar or identical transmembrane sequences (TMSs) showed a marked tendency to co-localize. Indeed we could predictably relocate proteins by swapping their TMSs. Finally, we found that the domain association of plasma-membrane proteins has an impact on their function. Our results are consistent with self-organization of biological membranes into a patchwork of coexisting domains.

Status: Epub ahead of print Type: Journal Article PubMed ID: 22544065

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Number of different genes curated to this paper: 49

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ATR1 BAP2 BIO5 BIT61 CAN1 CHO1 DNF1 ENA1 ENA2 FAA3
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Topics Genes linked to topics (#11 - 20 )
FET3 FET4 FLC1 FPS1 FTR1 FUI1 GAP1 GAS1 GPA1 HNM1
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Topics Genes linked to topics (#21 - 30 )
HXT2 HXT3 ITR2 MEP2 MID2 MNR2 MRH1 MSS4 NCE102 NHA1
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Topics Genes linked to topics (#31 - 40 )
PDR12 PDR5 PIL1 PMA1 PMP1 PSR1 RAS2 RAX2 RSN1 SHO1
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Topics Genes linked to topics (#41 - 49 )
SLN1 SSY1 SUR7 TCB3 THI7 TPO1 VHT1 YLR413W YOR1
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