SGD Paper 
Vitaliano-Prunier A, et al. (2012) H2B ubiquitylation controls the formation of export-competent mRNP. Mol Cell 45(1):132-9
Abstract: Histone H2B ubiquitylation is a transcription-dependent modification that not only regulates nucleosome dynamics but also controls the trimethylation of histone H3 on lysine 4 by promoting ubiquitylation of Swd2, a component of both the histone methyltransferase COMPASS complex and the cleavage and polyadenylation factor(CPF). We show that preventing either H2B ubiquitylation or H2B-dependent modification of Swd2 results in nuclear accumulation of poly(A) RNA due to a defect in the integrity and stability of APT, a subcomplex of the CPF. Ubiquitin-regulated APT complex dynamics is required for the correct recruitment of the mRNA export receptor Mex67 to nuclear mRNPs. While H2B ubiquitylation controls the recruitment of the different Mex67 adaptors to mRNPs, the effect of Swd2 ubiquitylation is restricted to Yra1 and Nab2, which, in turn, controls poly(A) tail length. Modification of H2B thus participates in the crosstalk between cotranscriptional events and assembly of mRNPs linking nuclear processing and mRNA export.CI - Copyright (c) 2012 Elsevier Inc. All rights reserved.
| Status: Published | Type: Journal Article | Research Support, Non-U.S. Gov't | PubMed ID: 22244335 |
Topics addressed in this paper
Number of different genes curated to this paper: 12
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| Topics | Genes linked to topics (#1 - 10 ) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| BRE1 | CBC2 | GAL10 | HTB1 | MEX67 | MTR2 | NAB2 | NPL3 | PMA1 | SET1 | |
| Additional Literature |  | | | | | | | | | |
| DNA/RNA Sequence Features | | |||||||||
| Mutants/Phenotypes | | | | |||||||
| Protein-Nucleic Acid Interactions | | | ||||||||
| Protein-protein Interactions | | | | | | |||||
| Regulation of | | |||||||||
| Topics | Genes linked to topics (#11 - 12 ) | |
|---|---|---|
| SWD2 | SYC1 | |
| Additional Literature | | |
| Genetic Interactions | | |
| Mutants/Phenotypes | | |
| Primary Literature | | |
| Protein Processing/Modification/Regulation | | |
| Protein-protein Interactions | | |
| Regulation of | | |
