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Massoni A, et al.  (2012) Proteome analysis of a CTR9 deficient yeast strain suggests that Ctr9 has function(s) independent of the Paf1 complex. Biochim Biophys Acta 1824(5):759-68

Abstract: The Ctr9 protein is a member of the Paf1 complex implicated in multiple functions: transcription initiation and elongation by RNA pol II, RNA processing and histone modifications. It has also been described as a triple-helical DNA binding protein. Loss of Ctr9 results in severe phenotypes similar to the loss of Paf1p, a Paf1 complex subunit. However, the exact role of Ctr9 is not entirely established. To study the biological role of the protein Ctr9 in yeast, we used 2-D gel electrophoresis and characterized proteome alterations in a ctr9? mutant strain. Here we present results suggesting that Ctr9 has function distinct from its established role in the Paf1 complex. This role could be linked to its ability to bind to DNA complex structures as triplexes that may have function in regulation of gene expression.

Status: Published Type: Journal Article PubMed ID: 22446411

Topics addressed in this paper

Number of different genes curated to this paper: 57

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
ADH1 ALD6 APA1 ARD1 ARG1 ARG3 ARG4 ARG7 ARG8 CAR1
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
DNA/RNA Sequence Features blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Large-scale protein detection yg ball
Omics yg ball
Primary Literature blue ball blue ball
Protein Processing/Modification/Regulation blue ball blue ball blue ball blue ball blue ball blue ball blue ball
RNA Levels and Processing blue ball blue ball blue ball blue ball blue ball
Transcription blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#11 - 20 )
CCT2 CDC48 CTR9 ENO1 ENO2 FSH1 GDH1 GLK1 GLO1 GND1
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
DNA/RNA Sequence Features blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Function/Process blue ball
Mutants/Phenotypes blue ball
Primary Literature blue ball blue ball
Protein Processing/Modification/Regulation blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Regulatory Role blue ball
RNA Levels and Processing blue ball
Transcription blue ball

Topics Genes linked to topics (#21 - 30 )
GVP36 HIS5 HRI1 HSP60 HYP2 LYS20 MET17 MET6 PAF1 PDA1
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
DNA/RNA Sequence Features blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Function/Process blue ball
Mutants/Phenotypes blue ball
Primary Literature blue ball
Protein Processing/Modification/Regulation blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Regulatory Role blue ball
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Topics Genes linked to topics (#31 - 40 )
PDB1 PGI1 PGK1 RHR2 RPN12 SAR1 SCL1 SER1 SER3 SFA1
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
DNA/RNA Sequence Features blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#41 - 50 )
SPE3 SUB2 SUP45 TDH2 TIF11 TIF2 TIF35 TPI1 TSA1 TUF1
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Transcription blue ball

Topics Genes linked to topics (#51 - 57 )
URA3 URA4 YDL124W YDR341C YHB1 YHI9 YNL010W
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DNA/RNA Sequence Features blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein Processing/Modification/Regulation blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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