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Fell GL, et al.  (2011) Identification of yeast genes involved in k homeostasis: loss of membrane traffic genes affects k uptake. G3 (Bethesda) 1(1):43-56

Abstract: Using the homozygous diploid Saccharomyces deletion collection, we searched for strains with defects in K(+) homeostasis. We identified 156 (of 4653 total) strains unable to grow in the presence of hygromycin B, a phenotype previously shown to be indicative of ion defects. The most abundant group was that with deletions of genes known to encode membrane traffic regulators. Nearly 80% of these membrane traffic defective strains showed defects in uptake of the K(+) homolog, (86)Rb(+). Since Trk1, a plasma membrane protein localized to lipid microdomains, is the major K(+) influx transporter, we examined the subcellular localization and Triton-X 100 insolubility of Trk1 in 29 of the traffic mutants. However, few of these showed defects in the steady state levels of Trk1, the localization of Trk1 to the plasma membrane, or the localization of Trk1 to lipid microdomains, and most defects were mild compared to wild-type. Three inositol kinase mutants were also identified, and in contrast, loss of these genes negatively affected Trk1 protein levels. In summary, this work reveals a nexus between K(+) homeostasis and membrane traffic, which does not involve traffic of the major influx transporter, Trk1.

Status: Published Type: Journal Article PubMed ID: 22384317

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Number of different genes curated to this paper: 161

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
ADH1 ADK1 ALG6 ANP1 APL2 ARF1 ARG82 ARL1 ARV1 BDF1
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BEM1 BRO1 BUR2 CDC40 CDC50 CHS5 CNB1 COG5 COG6 CSI2
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CTF4 CTK3 CYT1 DBP7 DHH1 DID4 EAF1 EFT2 ERG28 ERG3
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Topics Genes linked to topics (#31 - 40 )
FAB1 FYV4 GAS1 GEF1 GET1 GET2 GGA1 GGA2 GLO3 GOS1
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Topics Genes linked to topics (#41 - 50 )
GRR1 GTR2 GUP1 HAL5 HAP5 HMO1 HOC1 ILM1 IMP2' IRC10
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Topics Genes linked to topics (#51 - 60 )
IRS4 IST3 KAP120 KCS1 KRE28 LSB3 MDM20 MET22 MON1 MON2
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Topics Genes linked to topics (#61 - 70 )
NAT3 NBP2 NCS2 NCS6 NHX1 NOT5 NUP133 PEP12 PEP3 PEP5
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Topics Genes linked to topics (#71 - 80 )
PEP7 PER1 PHO80 PLC1 PMP3 POL32 PTC1 RAD50 RAD6 RAM1
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Topics Genes linked to topics (#81 - 90 )
REF2 REG1 RER1 RGP1 RIC1 ROT2 ROX3 RPB9 RPL21A RPL22A
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Topics Genes linked to topics (#91 - 100 )
RPL27A RPL31A RPP1B RTG1 RVS161 RVS167 SAC1 SAP155 SAT4 SCP160
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Topics Genes linked to topics (#101 - 110 )
SEC22 SFP1 SHP1 SIN3 SIS2 SIT4 SLG1 SLM4 SMI1 SNF3
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Topics Genes linked to topics (#111 - 120 )
SNF7 SNF8 SNX3 SPT20 SRB2 SRB5 SRF1 SSE1 SSZ1 STO1
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Topics Genes linked to topics (#121 - 130 )
STP22 SWA2 SYS1 TAF14 THO2 TIF4631 TLG2 TRK1 TUP1 UBX4
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Topics Genes linked to topics (#131 - 140 )
URE2 VAM3 VAM7 VAN1 VPH2 VPS1 VPS16 VPS20 VPS21 VPS24
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Topics Genes linked to topics (#141 - 150 )
VPS25 VPS27 VPS28 VPS29 VPS3 VPS30 VPS33 VPS36 VPS4 VPS41
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Topics Genes linked to topics (#151 - 160 )
VPS51 VPS52 VPS53 VPS54 VPS75 VPS8 VPS9 XRS2 YDR161W YPT6
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Topics Genes linked to topics (#161 )
ZUO1
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