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Chang HY, et al.  (2011) Genome-wide analysis to identify pathways affecting telomere-initiated senescence in budding yeast. G3 (Bethesda) 1(3):197-208

Abstract: In telomerase-deficient yeast cells, like equivalent mammalian cells, telomeres shorten over many generations until a period of senescence/crisis is reached. After this, a small fraction of cells can escape senescence, principally using recombination-dependent mechanisms. To investigate the pathways that affect entry into and recovery from telomere-driven senescence, we combined a gene deletion disrupting telomerase (est1Delta) with the systematic yeast deletion collection and measured senescence characteristics in high-throughput assays. As expected, the vast majority of gene deletions showed no strong effects on entry into/exit from senescence. However, around 200 gene deletions behaving similarly to a rad52Deltaest1Delta archetype (rad52Delta affects homologous recombination) accelerated entry into senescence, and such cells often could not recover growth. A smaller number of strains similar to a rif1Deltaest1Delta archetype (rif1Delta affects proteins that bind telomeres) accelerated entry into senescence but also accelerated recovery from senescence. Our genome-wide analysis identifies genes that affect entry into and/or exit from telomere-initiated senescence and will be of interest to those studying telomere biology, replicative senescence, cancer, and ageing. Our dataset is complementary to other high-throughput studies relevant to telomere biology, genetic stability, and DNA damage responses.

Status: Published Type: Journal Article PubMed ID: 22384331

Topics addressed in this paper

Number of different genes curated to this paper: 128

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Topics Genes linked to topics (#1 - 10 )
ARP6 ASF1 BRE1 CAC2 CDC73 CGR1 CHK1 CHO2 CIK1 CKB1
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Topics Genes linked to topics (#11 - 20 )
CTF18 CTF4 CTF8 CYK3 DCC1 DIA2 EAP1 EDE1 ELG1 ELM1
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Topics Genes linked to topics (#21 - 30 )
ELP2 ELP3 ELP4 ELP6 EST1 EST3 EXO1 GDA1 GOS1 GTR1
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Topics Genes linked to topics (#31 - 40 )
HDA1 HMO1 HSP104 HTZ1 HUR1 KAR3 LEA1 LST4 MED1 MED2
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Topics Genes linked to topics (#41 - 50 )
MEH1 MMM1 MMS1 MMS22 MRC1 MRE11 MRPL36 MTC1 NAM7 NHP10
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Topics Genes linked to topics (#51 - 60 )
NMD2 NOP12 NOP13 NPL4 NPT1 OPI1 PAR32 PHO80 PMR1 POL32
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Topics Genes linked to topics (#61 - 70 )
RAD27 RAD50 RAD52 RAD54 RAD55 RAD57 RAD9 RFM1 RHO4 RIF1
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Topics Genes linked to topics (#71 - 80 )
RIF2 RPL19A RPL21B RPL35B RPN4 RPS11B RPS16A RPS18B RPS4A RRP8
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Topics Genes linked to topics (#81 - 90 )
RTF1 RTT101 RTT107 RTT109 SCT1 SDS3 SEC28 SGF11 SGF29 SGF73
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Genetic Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Strains/Constructs blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Jump to Summary Chart for:
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  • To go to the Locus page for a gene, click on the gene name.

Topics Genes linked to topics (#91 - 100 )
SGS1 SHE1 SIN3 SLA1 SLX5 SLX8 SMI1 SNF8 SOH1 SPE3
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#101 - 110 )
SPT21 SUM1 SWC3 SWD1 SWD3 TEF4 TEL1 THR4 TIM18 TLG2
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Topics Genes linked to topics (#111 - 120 )
TMA19 TSA1 UBX2 UPF3 VAM3 VAM6 VAM7 VPS41 VPS75 XRN1
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Topics Genes linked to topics (#121 - 128 )
XRS2 YDL118W YDL183C YKU80 YPL205C YPR022C YPR084W YPT7
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