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Piggott N, et al.  (2011) Genome-wide Fitness Profiles Reveal a Requirement for Autophagy During Yeast Fermentation. G3 (Bethesda) 1(5):353-67

Abstract: The ability of cells to respond to environmental changes and adapt their metabolism enables cell survival under stressful conditions. The budding yeast Saccharomyces cerevisiae (S. cerevisiae) is particularly well adapted to the harsh conditions of anaerobic wine fermentation. However, S. cerevisiae gene function has not been previously systematically interrogated under conditions of industrial fermentation. We performed a genome-wide study of essential and nonessential S. cerevisiae gene requirements during grape juice fermentation to identify deletion strains that are either depleted or enriched within the viable fermentative population. Genes that function in autophagy and ubiquitin-proteasome degradation are required for optimal survival during fermentation, whereas genes that function in ribosome assembly and peroxisome biogenesis impair fitness during fermentation. We also uncover fermentation phenotypes for 139 uncharacterized genes with no previously known cellular function. We demonstrate that autophagy is induced early in wine fermentation in a nitrogen-replete environment, suggesting that autophagy may be triggered by other forms of stress that arise during fermentation. These results provide insights into the complex fermentation process and suggest possible means for improvement of industrial fermentation strains.FAU - Piggott, Nin.

Status: Published Type: Journal Article PubMed ID: 22384346

Topics addressed in this paper

Number of different genes curated to this paper: 63

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Topics Genes linked to topics (#1 - 10 )
APC1 ATG1 ATG10 ATG11 ATG12 ATG13 ATG14 ATG16 ATG18 ATG19
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Topics Genes linked to topics (#11 - 20 )
ATG2 ATG26 ATG29 ATG3 ATG31 ATG5 ATG7 ATG8 ATG9 CUE1
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Function/Process blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#21 - 30 )
CUE3 DOA1 ECM29 HRD1 IRS4 MDM30 MMS2 PEP4 POC4 PRE1
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Topics Genes linked to topics (#31 - 40 )
PRE2 PRE4 PRE7 PUP1 RFU1 RMD5 RPN5 RPT3 RPT5 RPT6
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Function/Process blue ball blue ball
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Topics Genes linked to topics (#41 - 50 )
SAN1 SKP2 SLX8 SNX4 SSM4 STS1 TOR1 UBC5 UBC7 UBI4
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Topics Genes linked to topics (#51 - 60 )
UBP1 UBP13 UBP14 UBP8 UBR2 UBX2 UFD2 UMP1 UTH1 VMS1
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Strains/Constructs blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#61 - 63 )
VPS30 YDR306C YLR224W
Additional Literature blue ball blue ball blue ball
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