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Ambroset C, et al.  (2011) Deciphering the molecular basis of wine yeast fermentation traits using a combined genetic and genomic approach. G3 (Bethesda) 1(4):263-81

Abstract: The genetic basis of the phenotypic diversity of yeast is still poorly understood. Wine yeast strains have specific abilities to grow and ferment under stressful conditions compared with other strains, but the genetic basis underlying these traits is unknown. Understanding how sequence variation influences such phenotypes is a major challenge to address adaptation mechanisms of wine yeast. We aimed to identify the genetic basis of fermentation traits and gain insight into their relationships with variations in gene expression among yeast strains. We combined fermentation trait QTL mapping and expression profiling of fermenting cells in a segregating population from a cross between a wine yeast derivative and a laboratory strain. We report the identification of QTL for various fermentation traits (fermentation rates, nitrogen utilization, metabolites production) as well as expression QTL (eQTL). We found that many transcripts mapped to several eQTL hotspots and that two of them overlapped with QTL for fermentation traits. A QTL controlling the maximal fermentation rate and nitrogen utilization overlapping with an eQTL hotspot was dissected. We functionally demonstrated that an allele of the ABZ1 gene, localized in the hotspot and involved in p-aminobenzoate biosynthesis, controls the fermentation rate through modulation of nitrogen utilization. Our data suggest that the laboratory strain harbors a defective ABZ1 allele, which triggers strong metabolic and physiological alterations responsible for the generation of the eQTL hotspot. They also suggest that a number of gene expression differences result from some alleles that trigger major physiological disturbances.FAU - Ambroset, Chlo.

Status: Published Type: Journal Article PubMed ID: 22384338

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ABZ1 ACT1 ADA2 ADH7 AIM23 ALG11 APM1 ARC1 ARC19 ARR1
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CDC12 CDC45 CDC7 CHO2 COA6 COB COX16 CRS5 CSM2 CTA1
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CTS1 CTT1 CUE5 CUP1-1 CUP1-2 CUS1 CYC1 CYS4 DAL7 DAL81
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DBP5 DCS2 DDC1 DDR2 ELA1 ENP2 ERG20 ERG24 FCP1 FCY1
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FMP48 FPK1 GCN3 GEA1 GFA1 GFD1 GIS3 GLC8 GLN1 GND2
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HCA4 HPA3 HRT3 HSP12 HSP30 HTA1 HXT13 HXT8 HYP2 IES5
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INP53 IRC25 JID1 JJJ2 JSN1 KES1 LHP1 LOA1 LYS12 LYS9
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MAE1 MAP1 MDM12 MEC3 MEP2 MOG1 MRS1 MSC1 MSC3 MSO1
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Topics Genes linked to topics (#91 - 100 )
MTF1 NCE102 NDD1 NOP19 NSA1 NSR1 OXR1 PAR32 PAU1 PAU10
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PAU13 PAU14 PAU23 PAU4 PAU7 PAU8 PDC5 PET18 PEX14 PEX29
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PGD1 PHM7 PIB2 PIN2 PLB2 PMP3 POL30 POP6 PRE1 PUP1
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PUT1 Q0182 RHO5 RNR2 RPL14A RPL14B RPL23B RPL25 RPN6 RPS10A
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RPS21A RSC58 SCM3 SCW4 SEG1 SFM1 SFT1 SGF11 SIP18 SKS1
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SMA1 SMD2 SME1 SMF3 SNG1 SOL2 SPC1 SPG1 SPO13 SPS100
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SPT7 SRB7 SSA4 SSZ1 STR3 SUP35 THI21 THI3 THI4 TIM21
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TMA23 TOA1 TOM7 TPK1 TPK3 TRP4 TVP23 UFD1 URA7 USB1
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VOA1 VPS24 YAR028W YAR069C YBL113C YBR013C YBR016W YCL076W YDL144C YDR261W-B
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YEL077C YFL002W-A YGL117W YGR026W YGR038C-B YGR093W YHB1 YHR097C YHR219W YIL067C
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YLR410W-B YLR444C YML131W YML133C YMR306C-A YNL108C YNL190W YNR048W YOL014W YOR277C
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YOR289W YOX1 YPC1 YPL080C YPL108W YPR137C-B YRF1-3 YRF1-6 YRF1-8 ZEO1
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