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Song W and Petes TD  (2012) Haploidization in Saccharomyces cerevisiae induced by a deficiency in homologous recombination. Genetics 191(1):279-84

Abstract: Diploid Saccharomyes cerevisae strains lacking the RAD52 gene required for homologous recombination have a very high rate of chromosome loss. Two of four isolates subcultured ~20 times (~500 cell divisions) became haploid. These strains were capable of mating with wild-type haploids to produce diploid progeny capable of undergoing meiosis to produce four viable spores.

Status: Published Type: Journal Article PubMed ID: 22367034

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